Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202104051
Abstract: Toll-like receptor (TLR) activation in macrophages plays a critical role in the pathogenesis of acute lung injury (ALI). While TLR inhibition is a promising strategy to control the overwhelming inflammation in ALI, there still lacks… read more here.
Keywords: proton pump; nano enabled; tlr; lung injury ... See more keywords
Toll-like receptor 3 (TLR-3), TLR-4 and CD80 expression in peripheral blood mononuclear cells and urinary CD80 levels in children with idiopathic nephrotic syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Nephrology"
DOI: 10.1007/s00467-017-3613-8
Abstract: BackgroundThe aims of this study were (1) to detect toll-like receptor (TLR)-3, TLR-4 and CD80 expression in peripheral blood mononuclear cells (PBMCs) and estimate urinary CD80 levels in children with idiopathic nephrotic syndrome and (2)… read more here.
Keywords: tlr tlr; tlr; urinary cd80; expression ... See more keywords
Molecular characterization of Pacific oyster (Crassostrea gigas) IRAK4 gene and its role in MyD88‐dependent pathway
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2017.02.004
Abstract: Abstract Interleukin‐1 receptor‐associated kinases (IRAKs) play important roles in MyD88‐dependent TLR signaling, the crucial innate immune pathway in molluscs. In this study, we examined the full‐length IRAK4 genetic sequence in the Pacific oyster (Crassostrea gigas)… read more here.
Keywords: oyster crassostrea; pacific oyster; crassostrea gigas; tlr ... See more keywords
Molecular cloning, characterization and function of a germinal center kinase MST4 gene from Litopenaeus vannamei in response to Vibrio alginolyticus challenge in TLR‐TRAF6 signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2017.03.026
Abstract: &NA; The serine/threonine protein kinase MST4 plays multiple roles in the regulation of signaling pathways that govern cellular processes including mitosis, migration, homeostasis, polarity, proliferation, differentiation and apoptosis. Here we report the identification and characterization… read more here.
Keywords: alginolyticus; response; lvmst4; kinase mst4 ... See more keywords
18F-fluorodeoxyglucose uptake in advanced gastric cancer correlates with histopathological subtypes and volume of tumor stroma.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2021.110048
Abstract: PURPOSE The aim of this study was to investigate the correlation between preoperative 18F-fluorodeoxyglucose (FDG) uptake and histological subtypes, amount of tumor stroma in advanced gastric cancer (GC), and clinical outcomes. METHODS We evaluated 56… read more here.
Keywords: cd34; uptake; tlr; suvmax ... See more keywords
Atorvastatin protected from paraquat-induced cytotoxicity in alveolar macrophages via down-regulation of TLR-4.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2016.11.011
Abstract: The current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat… read more here.
Keywords: alveolar macrophages; paraquat; tlr; induced cytotoxicity ... See more keywords
Isotrifoliol inhibits pro‐inflammatory mediators by suppression of TLR/NF‐&kgr;B and TLR/MAPK signaling in LPS‐induced RAW264.7 cells☆
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.01.033
Abstract: &NA; Soybeans, produced by Glycine max (L.) Merr., contain high levels of isoflavones, such as genistein and daidzein. However, soy leaves contain more diverse and abundant flavonol glycosides and coumestans, as compared to the soybean.… read more here.
Keywords: anti inflammatory; lps induced; isotrifoliol; tlr ... See more keywords
Both knock‐down and overexpression of Rap2a small GTPase in macrophages result in impairment of NF‐&kgr;B activity and inflammatory gene expression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2019.02.015
Abstract: &NA; Small Ras GTPases are key molecules that regulate a variety of cellular responses in different cell types. Rap1 plays important functions in the regulation of macrophage biology during inflammation triggered by toll‐like receptors (TLRs).… read more here.
Keywords: tlr; kgr activity; gene; activity ... See more keywords
Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarction.
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis research"
DOI: 10.1016/j.thromres.2017.07.031
Abstract: Both platelets and Toll-like receptors (TLRs) contribute to acute myocardial infarction (AMI). Platelet activation can occur post-AMI and despite treatment with anti-platelet therapy. TLRs may represent an alternative platelet activation pathway, although the role of… read more here.
Keywords: platelet activation; tlr; expression; activation ... See more keywords
Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b01473
Abstract: Small molecule Toll-like receptor-7 and -8 agonists (TLR-7/8a) can be used as vaccine adjuvants to induce CD8 T cell immunity but require formulations that prevent systemic toxicity and focus adjuvant activity in lymphoid tissues. Here,… read more here.
Keywords: polymer tlr; tlr; cd8 cell;
Tumor Microenvironment-Regulating Immunosenescence-Independent Nanostimulant Synergizing with Near-Infrared Light Irradiation for Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c20063
Abstract: The combination of photothermal therapy (PTT) and toll-like receptor (TLR)-mediated immunotherapy can elicit antitumor immunity and modulate the immunosuppressive tumor microenvironment (TME). Unlike other TLRs, TLR-5 is a promising target for immune activation, as its… read more here.
Keywords: antitumor immunity; immunosenescence independent; immunosenescence; tlr ... See more keywords