Prostate cancer cells modulate the differentiation of THP‐1 cells in response to etoposide and TLR agonists treatments
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11410
Abstract: The aim of this study was to determine the polarization of macrophages in the tumor microenvironment, as well as the effect of soluble factors secreted from these polarized macrophages on etoposide‐induced cancer cell apoptosis. We… read more here.
Keywords: pc3 cells; tlr agonists; cancer cells; cancer ... See more keywords
Effects of TLR agonists on immune responses in Trichinella spiralis infected mice
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology Research"
DOI: 10.1007/s00436-020-06747-8
Abstract: Human trichinellosis is acquired by eating raw or undercooked meats carrying muscle larvae of Trichinella spp. Toll-like receptors (TLRs) are essential components of the innate immune system. However, little is known about the potential application… read more here.
Keywords: tlr agonists; trichinella; trichinella spiralis; spiralis infection ... See more keywords
Toll-like receptor-targeted particles: A paradigm to manipulate the tumor microenvironment for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.05.043
Abstract: The expression of Toll-like receptors (TLRs) on antigen presenting cells, especially dendritic cells, offers several sensitive mediators to trigger an adaptive immune response, which potentially can be exploited to detect and eliminate pathogenic objects. Consequently,… read more here.
Keywords: cancer; toll like; tlr agonists; tumor ... See more keywords
TLR8 combined withTLR3 or TLR4 agonists enhances DC-NK driven effector Tc1 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.10.015
Abstract: BACKGROUND Most current prophylactic vaccines confer protection primarily through humoral immunity. Indeed, aluminum salts which have been widely used as adjuvants in vaccines primarily enhance Th2-driven antibody responses. Therefore, new vaccines formulation is moving toward… read more here.
Keywords: tlr3 tlr4; tlr agonists; effector cells; tc1 cells ... See more keywords
Intradermal co-inoculation of codon pair deoptimization (CPD)-attenuated chimeric porcine reproductive and respiratory syndrome virus (PRRSV) with Toll like receptor (TLR) agonists enhanced the protective effects in pigs against heterologous challenge.
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2021.109048
Abstract: The objective of this study was to assess protective efficacy of vaccination using CPD-attenuated chimeric PRRSV and Toll like receptor (TLR) agonists (HSP70 c-terminal domain and HSPX) as adjuvants through different inoculation routes. In this… read more here.
Keywords: cpd; cpd attenuated; attenuated chimeric; tlr agonists ... See more keywords
TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48073-y
Abstract: In this randomized phase II clinical trial, we evaluated the effectiveness of adding the TLR agonists, poly-ICLC or resiquimod, to autologous tumor lysate-pulsed dendritic cell (ATL-DC) vaccination in patients with newly-diagnosed or recurrent WHO Grade… read more here.
Keywords: tlr agonists; trial; dendritic cell; randomized phase ... See more keywords
Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity
Sign Up to like & getrecommendations! Published in 2019 at "NPJ Vaccines"
DOI: 10.1038/s41541-019-0119-3
Abstract: Neutralizing antibodies (nAbs) are a critical component for protection against dengue virus (DENV) infection, but little is known about the immune mechanisms governing their induction and whether such mechanisms can be harnessed for vaccine development.… read more here.
Keywords: infection; tlr agonists; immune signatures; dengue ... See more keywords
Novel TLR 7/8 agonists for improving NK cell mediated antibody-dependent cellular cytotoxicity (ADCC)
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83005-6
Abstract: There is a significant interest in designing therapeutic agents that can enhance ADCC and thereby improve clinical responses with approved antibodies. We recently reported the combination of an imidazoquinoline-based TLR7/8 agonist (522) with a monoclonal… read more here.
Keywords: cell mediated; agonists improving; novel tlr; antibody ... See more keywords
Molecule engineering strategy of toll-like receptor 7/8 agonists designed for potentiating immune stimuli activation.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical communications"
DOI: 10.1039/d4cc00792a
Abstract: Toll-like receptor 7/8 (TLR-7/8) agonists serve as a promising class of pattern recognition receptors that effectively evoke the innate immune response, making them promising immunomodulatory agents for tumor immunotherapy. However, the uncontrollable administration of TLR-7/8… read more here.
Keywords: tlr agonists; toll like; immune; like receptor ... See more keywords
Trial watch: Toll-like receptor ligands in cancer therapy
Sign Up to like & getrecommendations! Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2180237
Abstract: ABSTRACT Accumulating evidence indicates that Toll-like receptor (TLR) agonists proficiently (re)instore cancer immunosurveillance as immunological adjuvants. So far, three TLR agonists have been approved by regulatory agencies for use in oncological applications. Additionally, these immunotherapeutics… read more here.
Keywords: toll like; tlr agonists; like receptor; cancer ... See more keywords
Bibliometric analysis of toll-like receptor agonists associated with cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000028520
Abstract: Abstract Background: Toll-like receptors (TLRs), a family of innate pattern-recognition receptors, have been exploited as a target for antitumor strategy. An increasing number of TLR agonists, serving as immunotherapeutics or vaccine adjuvants, were developed. This… read more here.
Keywords: tlr; tlr agonists; bibliometric analysis; toll like ... See more keywords