Toll-like receptors change morphine-induced antinociception, tolerance and dependence: Studies using male and female TLR and signalling gene KO mice
Sign Up to like & getrecommendations! Published in 2022 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2022.02.001
Abstract: Toll-like receptors (TLR) have been proposed as a site of action that alters opioid pharmacodynamics. However, a comprehensive assessment of acute opioid antinociception, tolerance and withdrawal behaviours in genetic null mutant strains with altered innate… read more here.
Keywords: antinociception; antinociception tolerance; like receptors; tlr signalling ... See more keywords
Anticancer activity of IRAK-4 inhibitors against canine lymphoid malignancies.
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary and comparative oncology"
DOI: 10.1111/vco.12816
Abstract: The interleukin-1 receptor-related kinase 4 (IRAK4), downstream of myd88, plays an essential role in hyperactive TLR signaling seen in some B-cell lymphomas. In particular, efficient IRAK4 inhibitors of activated B-cell subtype of human diffuse large… read more here.
Keywords: cell; anticancer activity; tlr signalling; irak ... See more keywords