Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice
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DOI: 10.1186/s12974-020-01738-z
Abstract: Background Accumulating data suggest a central role for brain microglia in mediating cortical neuronal death in Alzheimer’s disease (AD), and for Toll-like receptor 2 (TLR2) in their toxic activation. Amyloid deposition in preclinical AD is… read more here.
Keywords: tlr2; microbial tlr2; alzheimer disease; 5xfad mice ... See more keywords