Calcitriol attenuates TLR2/IL-33 signaling pathway to repress Th9 cell differentiation and potentially limits the pathophysiology of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03914-4
Abstract: There is limited information regarding the TLR2 signaling pathway involved in Th9 cell differentiation. The role of calcitriol in regulating TLR2-mediated Th9 cell development is unknown. Thus, we aimed to unravel the TLR2 signaling pathway… read more here.
Keywords: th9; calcitriol; signaling pathway; th9 cell ... See more keywords
TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with downregulated expression of chemokines.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical science"
DOI: 10.1042/cs20220656
Abstract: Hereditary transthyretin amyloidosis (ATTRv) is a fatal neurodegenerative disorder, firstly identified in Portugal. The most common TTR mutation in ATTRv results from an exchange of a methionine for a valine at position 30 (V30M). ATTRv… read more here.
Keywords: ttr mice; expression; v30m ttr; tlr2 signaling ... See more keywords
Differential Effects of TLR1/2 and TLR2/6 Signaling on Normal and Premalignant Hematopoietic Stem and Progenitor Cells
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-119719
Abstract: Prior studies from our lab and others have demonstrated a role for Toll-like receptor 2 (TLR2) in regulating both normal and premalignant hematopoietic stem and progenitor cells (HSPCs), however the contributions of its binding partners,… read more here.
Keywords: pam3; treated pam2; mice treated; mice ... See more keywords
Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.963506
Abstract: Objectives: Osteoarthritis (OA) is a joint disease characterized by degeneration of joint cartilage and is a significant cause of severe joint pain, physical disability, and impaired quality of life in the aging population. Celastrol, a… read more here.
Keywords: celastrol ameliorates; signaling pathway; tlr2 signaling; celastrol ... See more keywords
Micro-Current Stimulation Suppresses Inflammatory Responses in Peptidoglycan-Treated Raw 264.7 Macrophages and Propionibacterium acnes-Induced Skin Inflammation via TLR2/NF-κB Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052508
Abstract: Acne is a common inflammatory disorder of the human skin and a multifactorial disease caused by the sebaceous gland and Propionibacterium acnes (P. acnes). This study aimed to evaluate the anti-inflammatory effect of micro-current stimulation… read more here.
Keywords: acnes induced; tlr2 signaling; induced skin; treated raw ... See more keywords
Activation of the Toll-like receptor 2 signaling pathway inhibits the proliferation of HCC cells in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Reports"
DOI: 10.3892/or.2019.7340
Abstract: Toll-like receptor 2 (TLR2), is an important pattern recognition receptor which serves a role in chronic inflammation of the liver. However, the role of TLR2 in the progression of human hepatocellular carcinoma (HCC) remains unknown.… read more here.
Keywords: hcc; proliferation; signaling pathway; activation ... See more keywords