Acute iron oxide nanoparticles exposure induced murine eosinophilic airway inflammation via TLR2 and TLR4 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23455
Abstract: Iron oxide nanoparticles (Fe2O3 NPs) is the main component of air pollution particles in urban rail transit environment. People are more exposed to Fe2O3 NPs, however, the studies on relationship between Fe2O3 NPs and respiratory… read more here.
Keywords: fe2o3 nps; airway inflammation; tlr2 tlr4;
Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists
Sign Up to like & getrecommendations! Published in 2018 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-018-1064-0
Abstract: BackgroundSepsis is more common in the elderly. TNF⍺ is recognized as an important mediator in sepsis and Toll-like receptors (TLRs) play an important role in initiating signaling cascades to produce TNF⍺. Little is known about… read more here.
Keywords: responses tlr2; year; tlr2 tlr4; tlr4 agonists ... See more keywords
TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid.
Sign Up to like & getrecommendations! Published in 2019 at "Biochimie"
DOI: 10.1016/j.biochi.2019.04.013
Abstract: Both hyperuricemia and adipose tissue renin-angiotensin system (RAS) are closely associated with multiple metabolic and cardiovascular diseases. We previously reported that uric acid could upregulate tissue RAS in adipocytes. In the present study, we aimed… read more here.
Keywords: uric acid; tlr2 tlr4; tissue; activation ... See more keywords
Co-stimulatory effect of TLR2 and TLR4 stimulation on megakaryocytic development is mediated through PI3K/NF-ĸB and XBP-1 loop.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109924
Abstract: Toll-like receptors (TLRs) are a class of proteins (patterns recognition receptors-PRRs) capable of recognizing molecules frequently found in pathogens (that are so-called pathogen-associated molecular patterns-PAMPs), they play a key role in the initiation of innate… read more here.
Keywords: stimulation; stimulatory effect; tlr2 tlr4; stimulation megakaryocytic ... See more keywords
Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2021.108702
Abstract: AIMS This research aimed to investigate the effects of high glucose(HG) on the innate immunity of podocytes and diabetic nephropathy (DN) mice via Toll like receptor (TLR) signaling, and explore the protective effectsof human umbilical… read more here.
Keywords: huc mscs; umbilical cord; tlr2 tlr4; human umbilical ... See more keywords
The oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 influences intracellular signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.12.004
Abstract: Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the… read more here.
Keywords: oxidation; cysteine; intracellular signaling; tlr2 tlr4 ... See more keywords
Bacteroidetes and Firmicutes levels in gut microbiota and effects of hosts TLR2/TLR4 gene expression levels in adult type 1 diabetes patients in Istanbul, Turkey.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2019.107449
Abstract: AIM The aim of this study was to determine and compare the levels of both Bacteroidetes and Firmicutes in the gut microbiota and TLR2/TLR4 gene expression in the blood of patients with type 1 diabetes… read more here.
Keywords: gene expression; tlr2 tlr4; gut microbiota; expression levels ... See more keywords
Immune effects of β-glucan are determined by combined effects on Dectin-1, TLR2, 4 and 5
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.07.061
Abstract: Abstract Particulate β-glucans enhanced NF-κB expression in cell-lines co-expressing Dectin-1A-TLR4 and Dectin-1B-TLR4, while soluble β-glucans only synergistically acted on Dectin-1A-TLR4. This was different with Dectin-1 co-expressing TLR2 and TLR5, which inhibited activation after particulate and… read more here.
Keywords: soluble glucan; particulate soluble; dectin tlr4; particulate ... See more keywords
Destruction in maternal-fetal interface of URSA patients via the increase of the HMGB1-RAGE/TLR2/TLR4-NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117543
Abstract: AIMS HMGB1 has been reported to play a crucial role in the physiological and pathophysiological responses during pregnancy. However, it is still unknown whether excessively expressed HMGB1 at the maternal-fetal interface related to Unexplained Recurrent… read more here.
Keywords: hmgb1; tlr2 tlr4; rage tlr2; maternal fetal ... See more keywords
Chlamydia trachomatis glycogen synthase promotes MAPK-mediated proinflammatory cytokine production via TLR2/TLR4 in THP-1 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119181
Abstract: AIMS To investigate the roles and mechanisms of C. trachomatis glycogen synthase (GlgA) in regulating the inflammatory response in THP-1 cells. MAIN METHODS In this work, after THP-1 cells were stimulated with GlgA, transcript and… read more here.
Keywords: glycogen synthase; trachomatis glycogen; tlr2 tlr4; thp cells ... See more keywords
Melanin of Sporothrix globosa affects the function of THP-1 macrophages and modulates the expression of TLR2 and TLR4.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2021.105158
Abstract: BACKGROUND Melanin is an important virulence factor for Sporothrix globosa, the causative agent of sporotrichosis, a subcutaneous mycosis that occurs worldwide. Although previous research suggests that melanin is involved in the pathogenesis of sporotrichosis, little… read more here.
Keywords: expression; globosa; tlr2 tlr4; melanin ... See more keywords