FAAH, but not MAGL, inhibition modulates acute TLR3‐induced neuroimmune signaling in the rat, independent of sex
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24120
Abstract: Toll‐like receptor (TLR)3 is a key component of the innate immune response to viral infection. The present study firstly examined whether sex differences exist in TLR3‐induced inflammatory, endocrine, and sickness responses. The data revealed that… read more here.
Keywords: faah; tlr3; tlr3 induced; independent sex ... See more keywords
Association of TLR3 functional variant (rs3775291) with COVID-19 susceptibility and death: a population-scale study
Sign Up to like & getrecommendations! Published in 2021 at "Human Cell"
DOI: 10.1007/s13577-021-00510-6
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the recent pandemic of coronavirus disease-19 (COVID-19) has a long, positive-sense, non-segmented single-stranded RNA (ssRNA) entrapped by an envelope with spikes. Although SARS-Cov2 infection is largely… read more here.
Keywords: tlr3; variant; study; covid ... See more keywords
TLR3 preconditioning induces anti-inflammatory and anti-ictogenic effects in mice mediated by the IRF3/IFN-β axis
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.07.021
Abstract: Activation of Toll-like receptor 3 (TLR3) was previously shown to contribute to the generation of epileptic seizures in rodents by evoking a proinflammatory response in the forebrain. This suggests that TLR3 blockade may provide therapeutic… read more here.
Keywords: tlr3; ifn; irf3 ifn; ifn axis ... See more keywords
Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFκB-RelA signaling in ARPE-19 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109494
Abstract: Dry age-related macular degeneration (AMD), accounting for approximately 90% of AMD cases, is characterized by photoreceptor death, retinal pigment epithelium (RPE) dysfunction and, ultimately, geographic atrophy - the localized death of RPE leading to loss… read more here.
Keywords: rela; tlr3; stat signaling; exposure ... See more keywords
Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2016.11.017
Abstract: Autophagy is involved in both innate and adaptive immune regulation. We propose that autophagy regulates activation of TLR3 in macrophages and is thereby essential for development of pristane-induced arthritis. We found that pristane treatment induced… read more here.
Keywords: stat1 irf1; pristane; irf1 tlr3; tlr3 ... See more keywords
Activation of Toll‐like receptor 3 promotes pathological corneal neovascularization by enhancement of SDF‐1‐mediated endothelial progenitor cell recruitment
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.10.005
Abstract: ABSTRACT Toll‐like receptors (TLRs) play an important role in inflammatory and immunological responses, which are intimately related to neovascularization. However, the precise mode of action of TLR3 in neovascularization still remains ambiguous. In this study,… read more here.
Keywords: toll like; pathological corneal; tlr3; corneal neovascularization ... See more keywords
TLR3 augments glucocorticoid-synthetic enzymes expression in epidermal keratinocytes; Implications of glucocorticoid metabolism in rosacea epidermis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.08.011
Abstract: BACKGROUND While most skin diseases benefit from topical steroids, rosacea symptoms are exacerbated by topical steroids. In the rosacea pathogenesis, abnormal innate immune mechanisms including overexpression of the Toll-like receptor (TLR) have been proposed. However,… read more here.
Keywords: synthetic enzymes; tlr3; epidermal keratinocytes; glucocorticoid synthetic ... See more keywords
Human prostate epithelial cells and prostate-derived stem cells malignantly transformed in vitro with sodium arsenite show impaired Toll like receptor -3 (TLR3)-associated anti-tumor pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.07.013
Abstract: A therapeutic strategy for prostate cancer (PCa) involves the use of 9-cis-retinoic acid (9cRA) to induce cancer stem cells (CSCs) differentiation and apoptosis. Polyinosinic:polycytidylic acid (PIC) is a Toll-like receptor 3 (TLR3) agonist that induces… read more here.
Keywords: tlr3; anti tumor; expression; stem ... See more keywords
Goose toll-like receptor 3 (TLR3) mediated IFN-γ and IL-6 in anti-H5N1 avian influenza virus response.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2018.01.010
Abstract: Induction of the innate immune pathways is critical for early anti-viral defense. How geese recognize viral molecules and activate these pathways is not well understood. In mammals, Toll-like receptor 3 (TLR3) recognizes double-stranded RNA. Activation… read more here.
Keywords: toll like; tlr3; h5n1; goose tlr3 ... See more keywords
De novo design of protein minibinder agonists of TLR3
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-56369-w
Abstract: Toll-like Receptor 3 (TLR3) is a pattern recognition receptor that initiates antiviral immune responses upon binding double-stranded RNA (dsRNA). Several nucleic acid-based TLR3 agonists have been explored clinically as vaccine adjuvants in cancer and infectious… read more here.
Keywords: design protein; pattern recognition; tlr3; design ... See more keywords
Pattern-recognition receptors in duck (Anas platyrhynchos): identification, expression and function analysis of toll-like receptor 3
Sign Up to like & getrecommendations! Published in 2020 at "British Poultry Science"
DOI: 10.1080/00071668.2020.1853045
Abstract: ABSTRACT 1. Innate immunity provides the first line of defence against pathogenic organisms through a myriad of germline encoded receptors called pattern-recognition receptors (PRRs). Toll-like receptor (TLR) 3, as an important member of PRRs, is… read more here.
Keywords: pattern recognition; toll like; recognition receptors; anas platyrhynchos ... See more keywords