Pharmacological inhibition of Kv1.3 channel impairs TLR3/4 activation and type I IFN response and confers protection against Listeria monocytogenes infection.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106112
Abstract: Emerging data have demonstrated the critical roles of potassium efflux in the innate immune system. However, the role of potassium efflux in TLR3/4 activation and type I interferon (IFN) responses are not well elucidated. In… read more here.
Keywords: kv1 channel; ifn; activation; inhibition kv1 ... See more keywords
Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study
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DOI: 10.3389/fphys.2019.00306
Abstract: Toll-like receptor (TLR)3 activation during the neonatal period produces responses linked to the origins of neuropsychiatric disorders. Although there is sexual dimorphism in neuropsychiatric disorders, it is unknown if brain responses to TLR3 activation are… read more here.
Keywords: tlr3 activation; female mice; activation; gene ... See more keywords