TLR3 agonism re‐establishes CNS immune competence during α4‐integrin deficiency
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DOI: 10.1002/acn3.664
Abstract: Natalizumab blocks α4‐integrin‐mediated leukocyte migration into the central nervous system (CNS). It diminishes disease activity in multiple sclerosis (MS), but carries a high risk of progressive multifocal encephalopathy (PML), an opportunistic infection with JV virus… read more here.
Keywords: tlr3 agonism; cns immune; immune competence; integrin deficiency ... See more keywords