RING finger protein TOPORS modulates the expression of tumor suppressor SMAR1 in colorectal cancer via the TLR4-TRIF pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13126
Abstract: TOP1-binding arginine/serine-rich protein (TOPORS), a RING finger protein, has the ability to bind to a palindromic consensus DNA sequence that enables it to function as a potential transcriptional regulator. However, its role in regulating the… read more here.
Keywords: protein; ring finger; cancer; tlr4 ... See more keywords
The rapid endocytic uptake of fetuin‐A by adherent tumor cells is mediated by Toll‐like receptor 4 (TLR4)
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13008
Abstract: Fetuin‐A is a serum glycoprotein synthesized and secreted into blood by the liver and whose main physiological function is the inhibition of ectopic calcification. However, a number of studies have demonstrated that it is a… read more here.
Keywords: tumor; tumor cells; tlr4; receptor ... See more keywords
Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202414956
Abstract: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, accounting for ≈60–70% of all dementia cases worldwide. Microglial‐mediated brain inflammation is thought to play key roles in AD progression. Clinical evidence and animal models have… read more here.
Keywords: alzheimer disease; brain inflammation; tlr4; tlr4 mrna ... See more keywords
S100a8/a9 regulated by LPS/TLR4 axis plays an important role in Salmonella‐based tumor therapy and host defense
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Cancer"
DOI: 10.1002/ijc.35128
Abstract: Bacteria are ideal anticancer agents and carriers due to their unique capabilities that are convenient in genetic manipulation, tumor‐specific targeting, and deep‐tissue penetration. However, the specific molecular mechanisms of bacteria‐mediated cancer therapy (BMCT) have not… read more here.
Keywords: cancer; therapy; salmonella; tlr4 ... See more keywords
PTPRO exaggerates inflammation in ulcerative colitis through TLR4/NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29343
Abstract: Previous studies have implicated protein tyrosine phosphatase receptor type O (PTPRO) as a key regulator in inflammation‐associated diseases; however, its role in ulcerative colitis (UC) remains largely unknown. Thus, we aim to elucidate the potential… read more here.
Keywords: exaggerates inflammation; inflammation ulcerative; ulcerative colitis; ptpro exaggerates ... See more keywords
Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll‐like receptor 4
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27929
Abstract: Renal proximal tubular cells (PTECs) participate in several mechanisms of innate immunity, express toll‐like receptors (TLRs), and proinflammatory cytokines. Hyperuricemia may be a promoter of inflammation and renal damage. Angiotensin II (Ang II) modulate immune… read more here.
Keywords: toll like; uric acid; inflammation; tlr4 ... See more keywords
One functional variant in the 3′‐untranslated region of TLR4 is associated with the elevated risk of ventilator‐associated pneumonia in the patients with chronic obstructive pulmonary disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28526
Abstract: The aim of this study was to identify the association polymorphism (rs11536889) in the 3′‐untranslated region (3′‐UTR) of Toll‐like receptors 4 (TLR4) and the risk for ventilator‐associated pneumonia (VAP). miRNA database online and luciferase assays… read more here.
Keywords: risk; ventilator associated; associated pneumonia; risk ventilator ... See more keywords
Gender differences in Alzheimer's may be associated with TLR4-LYN expression in damage associated microglia and neuronal phagocytosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30916
Abstract: The role of Aβ plaques and neurofibrillary tangles in Alzheimer's disease (AD) pathogenesis have recently come into question due to failure of many pharmaceutical agents targeting these deposits and detection of these misfolded proteins in… read more here.
Keywords: tlr4; associated microglia; phagocytosis; tlr4 lyn ... See more keywords
Tannic acid alleviates ETEC K88-induced intestinal damage through regulating the p62-keap1-Nrf2 and TLR4-NF-κB-NLRP3 pathway in IPEC-J2 cells.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.13343
Abstract: BACKGROUND Tannic acid (TA), a naturally occurring polyphenol, has shown diverse potential in preventing intestinal damage in piglet diarrhea induced by ETEC K88. However, the protective effect of TA on ETEC k88 infection-induced post-weaning diarrhea… read more here.
Keywords: k88; damage; etec k88; tlr4 ... See more keywords
Transcription Factor FOXD3 Regulates ELAV1/TLR4 Axis in Antiphospholipid Syndrome to Mediate Proliferation and Migration of Trophoblasts
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.70021
Abstract: This study focused on exploring the mechanism of transcription factor FOXD3 promoting the proliferation, migration, and invasion of trophoblast through ELAV1/TLR4 axis. The placenta villi from pregnancy patients with antiphospholipid syndrome (APS) and pregnancy controls… read more here.
Keywords: elav1 tlr4; migration; tlr4; cell ... See more keywords
Tracing the evolution of novel features of human Toll‐like receptor 4
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3644
Abstract: Toll‐like receptor 4 (TLR4) is a critical innate immune protein that activates inflammation in response to extracellular cues. Much of the work to understand how the protein works in humans has been done using mouse… read more here.
Keywords: toll like; human tlr4; like receptor; mouse tlr4 ... See more keywords