RING finger protein TOPORS modulates the expression of tumor suppressor SMAR1 in colorectal cancer via the TLR4-TRIF pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13126
Abstract: TOP1-binding arginine/serine-rich protein (TOPORS), a RING finger protein, has the ability to bind to a palindromic consensus DNA sequence that enables it to function as a potential transcriptional regulator. However, its role in regulating the… read more here.
Keywords: protein; ring finger; cancer; tlr4 ... See more keywords
The rapid endocytic uptake of fetuin‐A by adherent tumor cells is mediated by Toll‐like receptor 4 (TLR4)
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13008
Abstract: Fetuin‐A is a serum glycoprotein synthesized and secreted into blood by the liver and whose main physiological function is the inhibition of ectopic calcification. However, a number of studies have demonstrated that it is a… read more here.
Keywords: tumor; tumor cells; tlr4; receptor ... See more keywords
PTPRO exaggerates inflammation in ulcerative colitis through TLR4/NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29343
Abstract: Previous studies have implicated protein tyrosine phosphatase receptor type O (PTPRO) as a key regulator in inflammation‐associated diseases; however, its role in ulcerative colitis (UC) remains largely unknown. Thus, we aim to elucidate the potential… read more here.
Keywords: exaggerates inflammation; inflammation ulcerative; ulcerative colitis; ptpro exaggerates ... See more keywords
Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll‐like receptor 4
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27929
Abstract: Renal proximal tubular cells (PTECs) participate in several mechanisms of innate immunity, express toll‐like receptors (TLRs), and proinflammatory cytokines. Hyperuricemia may be a promoter of inflammation and renal damage. Angiotensin II (Ang II) modulate immune… read more here.
Keywords: toll like; uric acid; inflammation; tlr4 ... See more keywords
One functional variant in the 3′‐untranslated region of TLR4 is associated with the elevated risk of ventilator‐associated pneumonia in the patients with chronic obstructive pulmonary disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28526
Abstract: The aim of this study was to identify the association polymorphism (rs11536889) in the 3′‐untranslated region (3′‐UTR) of Toll‐like receptors 4 (TLR4) and the risk for ventilator‐associated pneumonia (VAP). miRNA database online and luciferase assays… read more here.
Keywords: risk; ventilator associated; associated pneumonia; risk ventilator ... See more keywords
Gender differences in Alzheimer's may be associated with TLR4-LYN expression in damage associated microglia and neuronal phagocytosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30916
Abstract: The role of Aβ plaques and neurofibrillary tangles in Alzheimer's disease (AD) pathogenesis have recently come into question due to failure of many pharmaceutical agents targeting these deposits and detection of these misfolded proteins in… read more here.
Keywords: tlr4; associated microglia; phagocytosis; tlr4 lyn ... See more keywords
Tracing the evolution of novel features of human Toll‐like receptor 4
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3644
Abstract: Toll‐like receptor 4 (TLR4) is a critical innate immune protein that activates inflammation in response to extracellular cues. Much of the work to understand how the protein works in humans has been done using mouse… read more here.
Keywords: toll like; human tlr4; like receptor; mouse tlr4 ... See more keywords
Loureirin C ameliorates ischemia and reperfusion injury in rats by inhibiting the activation of the TLR4/NF‐κB pathway and promoting TLR4 degradation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7571
Abstract: Ischemic stroke is a leading cause of death and disability worldwide. Post‐ischemia, microglia respond immediately to the alternations in neuronal activity and mediate inflammation. Toll‐like receptor 4 (TLR4) plays a key role in this phenomenon.… read more here.
Keywords: loureirin; ischemic stroke; reperfusion; degradation ... See more keywords
Salidroside ameliorates pathological cardiac hypertrophy via TLR4‐TAK1‐dependent signaling
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7701
Abstract: Salidroside, a prominent active ingredient in traditional Chinese medicines, is garnering increased attention because of its unique pharmacological effects against ischemic heart disease via MAPK signaling, which plays a critical role in regulating the evolution… read more here.
Keywords: hypertrophy; jnk p38; tak1; tlr4 ... See more keywords
Perfluorooctane sulfonate aggravates CCl4‐induced hepatic fibrosis via HMGB1/TLR4/Smad signaling
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23458
Abstract: Perfluorooctane sulfonate (PFOS) is a widespread environmental pollutant and may cause a variety of adverse health effects. The hepatotoxicity of PFOS has attracted particular attention, given the fact that the liver has one of the… read more here.
Keywords: pfos; tlr4; pfos exposure; via hmgb1 ... See more keywords
Triphenyl phosphate-induced macrophages dysfunction by activation TLR4-mediated ERK/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23778
Abstract: Triphenyl phosphate (TPHP) is one of the most widely used organic phosphorus flame retardants and is ubiquitous in the environment. Studies have been reported that TPHP may lead to obesity, neurotoxicity and reproductive toxicity, but… read more here.
Keywords: erk pathway; triphenyl phosphate; tlr4 mediated; mediated erk ... See more keywords