1734: TOLL-LIKE RECEPTOR 4 CONTRIBUTES TO VASODILATORY SHOCK VIA ALPHA ADRENERGIC RECEPTOR INTERNALIZATION
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000649232.13897.7a
Abstract: Introduction/Hypothesis: Vasodilatory shock is characterized by vascular resistance failure resulting from the inability of vascular smooth muscle to vasoconstrict appropriately. Refractory vascular failure is thus a final common pathway for severe shock of any cause.… read more here.
Keywords: a1ar; tlr4 activation; receptor; adrenergic receptor ... See more keywords
TLR4 Activation Promotes the Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy by Inducing Mitochondrial Dynamic Imbalance
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/3181278
Abstract: Mitochondrial dynamic imbalance associates with several cardiovascular diseases. However, the role of mitochondrial dynamics in TLR4 activation-mediated dilated cardiomyopathy (DCM) progress remains unknown. A model of experimental autoimmune myocarditis (EAM) was established in BALB/c mice… read more here.
Keywords: mitochondrial dynamic; tlr4 activation; activation; dynamic imbalance ... See more keywords
Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88- and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection
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DOI: 10.3389/fimmu.2021.626110
Abstract: TLR4 activates two distinct signaling pathways involving adaptors MyD88 and TRIF to produce proinflammatory cytokines and type-I interferon respectively. How Leishmania donovani suppresses these pathways is not well studied. We earlier reported, TLR4 is hypersialylated… read more here.
Keywords: tlr4 activation; sialic acids; infection; myd88 trif ... See more keywords
TLR4 activation by lysozyme induces pain without inflammation
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DOI: 10.3389/fimmu.2023.1065226
Abstract: Mostly, pain has been studied in association with inflammation, until recent studies which indicate that during bacterial infections, pain mechanisms could be independent of the inflammation. Chronic pain can sustain long after the healing from… read more here.
Keywords: inflammation; tlr4 activation; induces pain; lysozyme induces ... See more keywords
Persistent TLR4 Activation Promotes Hepatocellular Carcinoma Growth through Positive Feedback Regulation by LIN28A/Let-7g miRNA
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158419
Abstract: Chronic inflammation caused by liver damage or infection plays an important role in the development and progression of hepatocellular carcinoma (HCC). The activation of Toll-like receptors 4 (TLR4) is involved in HCC tumorigenesis. Moreover, high… read more here.
Keywords: tlr4 activation; let mirna; hcc; expression ... See more keywords