Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists
Sign Up to like & getrecommendations! Published in 2018 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-018-1064-0
Abstract: BackgroundSepsis is more common in the elderly. TNF⍺ is recognized as an important mediator in sepsis and Toll-like receptors (TLRs) play an important role in initiating signaling cascades to produce TNF⍺. Little is known about… read more here.
Keywords: responses tlr2; year; tlr2 tlr4; tlr4 agonists ... See more keywords
TLR4-Based Immunotherapeutics in Cancer: A Review of the Achievements and Shortcomings.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00691
Abstract: Toll-like Receptor 4 (TLR4) agonists have had a long journey in the field of cancer immunotherapy. Nevertheless, despite the remarkable number of the TLR4 ligands that have gone through various preclinical and clinical stages, only… read more here.
Keywords: achievements shortcomings; tlr4 agonists; review; cancer immunotherapy ... See more keywords
The differences in immunoadjuvant mechanisms of TLR3 and TLR4 agonists on the level of antigen-presenting cells during immunization with recombinant adenovirus vector
Sign Up to like & getrecommendations! Published in 2018 at "BMC Immunology"
DOI: 10.1186/s12865-018-0264-x
Abstract: BackgroundAgonists of TLR3 and TLR4 are effective immunoadjuvants for different types of vaccines. The mechanisms of their immunostimulatory action differ significantly; these differences are particularly critical for immunization with non-replicating adenovirus vectors (rAds) based vaccines.… read more here.
Keywords: presenting cells; tlr3 tlr4; agonists level; tlr4 agonists ... See more keywords
Pro-inflammatory response ensured by LPS and Pam3CSK4 in RAW 264.7 cells did not improve a fungistatic effect on Cryptococcus gattii infection
Sign Up to like & getrecommendations! Published in 2020 at "PeerJ"
DOI: 10.7717/peerj.10295
Abstract: Background The macrophage lineage is characterized by plasticity due to the acquisition of distinct functional phenotypes, and two major subsets are evaluated; classical M1 activation (strong microbicidal activity) and alternative M2 activation (immunoregulatory functions). The… read more here.
Keywords: raw 264; gattii; tlr2 tlr4; tlr4 agonists ... See more keywords