Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways
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DOI: 10.3389/fimmu.2020.585146
Abstract: The innate immune response to lipopolysaccharide is essential for host defense against Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is expressed on the surface of macrophages, monocytes, dendritic, and epithelial cells… read more here.
Keywords: tlr4 caspase; caspase; caspase mediated; tlr4 complex ... See more keywords
Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics
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DOI: 10.3390/ph16010023
Abstract: The Toll-like receptor 4 (TLR4) signaling pathway plays a central role in the prompt defense against infectious challenge and provides immediate response to Gram-negative bacterial infection. The TLR4/MD-2 complex can sense and respond to various… read more here.
Keywords: inflammation; infection; therapeutic targeting; tlr4 complex ... See more keywords