Deficiency of inhibitory TLR4 homolog RP105 exacerbates fibrosis
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DOI: 10.1172/jci.insight.160684
Abstract: Activation of TLR4 by its cognate damage-associated molecular patterns (DAMPs) elicits potent profibrotic effects and myofibroblast activation in systemic sclerosis (SSc), while genetic targeting of TLR4 or its DAMPs in mice accelerates fibrosis resolution. To… read more here.
Keywords: tlr4 homolog; tlr4; rp105; ssc skin ... See more keywords