Dexmedetomidine promotes liver regeneration in mice after 70% partial hepatectomy by suppressing NLRP3 inflammasome not TLR4/NF&kgr;B
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.10.030
Abstract: ABSTRACT Inflammasome activation is mediated by NOD‐like receptors (NLRs) that play important role in cellular proliferation. NLRP3 senses the widest array of stimuli. But its role in the liver regeneration after partial hepatectomy (PHx) is… read more here.
Keywords: phx; liver regeneration; tlr4 kgr; dex ... See more keywords
Liver nitrosation and inflammation in septic rats were suppressed by propofol via downregulating TLR4/NF‐&kgr;B‐mediated iNOS and IL‐6 gene expressions
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.01.005
Abstract: Aims: Propofol can be applied as an anesthetic or sedative agent for septic patients. Our previous studies showed that propofol ameliorated inflammation‐ and nitrosative stress‐induced cellular insults. This study further evaluated effects of propofol on… read more here.
Keywords: clp; gene expressions; clp induced; inos gene ... See more keywords
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF‐&kgr;B signaling pathway in a mouse model of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.03.030
Abstract: Abstract Inflammation contributes to the pathological processes in patients and animal models of PD. Rosmarinic acid (RA) has been demonstrated to protect neurons in PD models. The present study aimed to evaluate the anti‐inflammatory effect… read more here.
Keywords: inflammatory responses; hmgb1 tlr4; rosmarinic acid; kgr signaling ... See more keywords
Pharmacological Inhibition of Macrophage Toll-like Receptor 4/Nuclear Factor-kappa B Alleviates Rhabdomyolysis-induced Acute Kidney Injury
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Medical Journal"
DOI: 10.4103/0366-6999.213406
Abstract: Background: Acute kidney injury (AKI) is the most common and life-threatening systemic complication of rhabdomyolysis. Inflammation plays an important role in the development of rhabdomyolysis-induced AKI. This study aimed to investigate the kidney model of… read more here.
Keywords: rhabdomyolysis; tlr4 kgr; macrophage; rhabdomyolysis induced ... See more keywords