Triphenyl phosphate-induced macrophages dysfunction by activation TLR4-mediated ERK/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23778
Abstract: Triphenyl phosphate (TPHP) is one of the most widely used organic phosphorus flame retardants and is ubiquitous in the environment. Studies have been reported that TPHP may lead to obesity, neurotoxicity and reproductive toxicity, but… read more here.
Keywords: erk pathway; triphenyl phosphate; tlr4 mediated; mediated erk ... See more keywords
Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.01.049
Abstract: Prenatal alcohol exposure (PAE) could lead to developmental disorders of the central nervous system (CNS) and mental retardation. Toll-like receptor (TLR) 4 plays an important role in PAE-induced neurodevelopmental defects. However, how PAE affects TLR4… read more here.
Keywords: prenatal alcohol; response; pae; alcohol exposure ... See more keywords
Sphingolipid metabolism during TLR4-mediated macrophage activation.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15642
Abstract: Macrophage activation in response to stimulation of Toll-like receptor 4 (TLR4) provides a paradigm for investigating energy metabolism that regulate the inflammatory response. TLR4-mediated pro-inflammatory macrophage activation is characterised by increased glycolysis and altered mitochondrial… read more here.
Keywords: macrophage activation; metabolism; activation; tlr4 ... See more keywords
TLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Brain"
DOI: 10.1186/s13041-018-0354-y
Abstract: Neuropathic pain is a complex, chronic pain state characterized by hyperalgesia, allodynia, and spontaneous pain. Accumulating evidence has indicated that the microglial Toll-like receptor 4 (TLR4) and autophagy are implicated in neurodegenerative diseases, but their… read more here.
Keywords: group; mice; neuropathic pain; tlr4 ... See more keywords
Autotaxin loss accelerates intestinal inflammation by suppressing TLR4‐mediated immune responses
Sign Up to like & getrecommendations! Published in 2020 at "EMBO reports"
DOI: 10.15252/embr.201949332
Abstract: Autotaxin (ATX) converts lysophosphatidylcholine and sphingosyl‐phosphorylcholine into lysophosphatidic acid and sphingosine 1‐phosphate, respectively. Despite the pivotal function of ATX in lipid metabolism, mechanisms by which ATX regulates immune and inflammatory disorders remain elusive. Here, using… read more here.
Keywords: loss accelerates; immune responses; inflammation; tlr4 ... See more keywords
Lipopolysaccharide Upregulated Intestinal Epithelial Cell Expression of Fn14 and Activation of Fn14 Signaling Amplify Intestinal TLR4-Mediated Inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00315
Abstract: TLR4 in intestinal epithelial cells has been shown both inflammatory and homeostatic roles following binding of its cognate ligand lipopolysaccharide (LPS). TWEAK-Fn14 axis plays an important role in pathologies caused by excessive or abnormal inflammatory… read more here.
Keywords: intestinal epithelial; fn14; fn14 activation; expression fn14 ... See more keywords
Insight Into TLR4-Mediated Immunomodulation in Normal Pregnancy and Related Disorders
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00807
Abstract: Unlike organ transplants where an immunosuppressive environment is required, a successful pregnancy involves an extremely robust, dynamic, and responsive maternal immune system to maintain the development of the fetus. A specific set of hormones and… read more here.
Keywords: pregnancy; pregnancy related; tlr4; immune cells ... See more keywords
STAT3 Differentially Regulates TLR4-Mediated Inflammatory Responses in Early or Late Phases
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21207675
Abstract: Toll-like receptor 4 (TLR4) signaling is an important therapeutic target to manage lipopolysaccharide (LPS)-induced inflammation. The transcription factor signal transducer and activator of transcription 3 (STAT3) has been identified as an important regulator of various… read more here.
Keywords: differentially regulates; mediated inflammatory; early late; tlr4 ... See more keywords