Eupatilin alleviates inflammatory response after subarachnoid hemorrhage by inhibition of TLR4/MyD88/NF‐κB axis
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DOI: 10.1002/jbt.23317
Abstract: Early brain injury (EBI) is associated with the adverse prognosis of subarachnoid hemorrhage (SAH) patients. The key bioactive component of the Chinese herbal medicine Artemisia asiatica Nakai (Asteraceae) is eupatilin. Recent research reports that eupatilin… read more here.
Keywords: subarachnoid hemorrhage; brain; eupatilin; tlr4 myd88 ... See more keywords
Paeonol Alleviates Subarachnoid Hemorrhage Injury in Rats Through Upregulation of SIRT1 and Inhibition of HMGB1/TLR4/MyD88/NF‐κB Pathway
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DOI: 10.1002/jbt.70035
Abstract: Paeonol is a principle bioactive compound separated from the root bark of Cortex Moutan and has been shown to confer various biological functions, including antineuroinflammation and neuroprotection. Inflammation, blood–brain barrier (BBB), permeability, and apoptosis are… read more here.
Keywords: brain; inhibition; myd88 pathway; sirt1 inhibition ... See more keywords
Synergistic anti‐inflammatory effects of quercetin and catechin via inhibiting activation of TLR4–MyD88‐mediated NF‐κB and MAPK signaling pathways
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DOI: 10.1002/ptr.6268
Abstract: The synergistic anti‐inflammatory effect of quercetin and catechin was investigated using lipopolysaccharide (LPS)‐stimulated macrophage RAW 264.7 cells. Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS‐stimulated increase of some proinflammatory molecules,… read more here.
Keywords: anti inflammatory; quercetin catechin; synergistic anti; tlr4 myd88 ... See more keywords
Astragaloside IV Pretreatment Alleviates Pulmonary Ischemia–Reperfusion Injury via the TLR4/MyD88/NF‐κB p65 Pathway in Rats
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DOI: 10.1002/ptr.70039
Abstract: Background and aim Our previous study confirmed that ASIV can protect the lung from ischemia–reperfusion injury. The aim of this study was to determine whether ASIV attenuates PIRI by inhibiting the activation of the TLR4/MyD88/NF‐κBp65… read more here.
Keywords: tlr4 myd88; ischemia reperfusion; tlr4; reperfusion injury ... See more keywords
Artemisinin Alleviates Chronic Social Defeat Stress‐Induced Depressive‐Like Behavior by Inhibiting Neuroinflammation via the TLR4/MyD88/NF‐κB/NLRP3 Signaling Pathway
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DOI: 10.1002/ptr.70106
Abstract: Neuroinflammation caused by neuroimmune dysfunction is important for the pathogenesis of major depressive disorders; new antidepressant treatments are urgently needed. Artemisinin (ART) has anti‐inflammatory and neuroprotective effects; it can alleviate the inflammatory response in the… read more here.
Keywords: tlr4 myd88; like behavior; neuroinflammation; signaling pathway ... See more keywords
Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway
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DOI: 10.1007/s13659-024-00458-8
Abstract: Adenosma buchneroides Bonati, also known as fleagrass, is an important medicinal plant used by the Akha (Hani) people of China for treating inflammation-related skin swelling, acne, and diarrhoea, among other conditions. In this study, we… read more here.
Keywords: buchneroides bonati; tlr4 myd88; fleagrass; adenosma buchneroides ... See more keywords
Anethole's effects against myocardial infarction: The role of TLR4/NFκB and Nrf2/HO1 pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2022.109947
Abstract: BACKGROUND Exploring new drugs for the management of myocardial infarction (MI) is crucial, as MI is a major contributor to mortality worldwide. Anethole, a naturally occurring essential oil component, has numerous medicinal, pharmaceutical, and cosmetic… read more here.
Keywords: effects myocardial; anethole effects; tlr4 myd88; tlr4 ... See more keywords
EphA2 antagonism alleviates LPS-induced acute lung injury via Nrf2/HO-1, TLR4/MyD88 and RhoA/ROCK pathways.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.04.008
Abstract: Eph receptor tyrosine kinases have a wide range of biological functions and have gradually been recognized increasingly as key regulators of inflammation and injury diseases. Although previous studies suggested that EphA2 receptor may be involved… read more here.
Keywords: tlr4 myd88; lps induced; epha2 antagonism; rhoa rock ... See more keywords
Eupatilin attenuates the inflammatory response induced by intracerebral hemorrhage through the TLR4/MyD88 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105837
Abstract: BACKGROUND Intracranial hemorrhage (ICH) is one of the most common brain traumas, and inflammation caused by ICH seriously affects the quality of life and prognosis of patients. Eupatilin has been shown to have anti-inflammatory effects… read more here.
Keywords: tlr4 myd88; inflammatory response; hemorrhage; myd88 pathway ... See more keywords
Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF-κB signaling downregulation partly via cholinergic anti-inflammatory mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105898
Abstract: BACKGROUND Uncontrolled inflammatory responses exacerbate the pathogenesis of septic acute liver injury (ALI), posing a lethal threat to the host. Dexmedetomidine (DEX) has been reported to possess protective properties in inflammatory conditions. This study aimed… read more here.
Keywords: tlr4 myd88; lps; dex; myd88 signaling ... See more keywords
Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney by regulating the Nrf2/TLR4/MyD88 and PPAR-γ/TGF-β1/Smad3 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107117
Abstract: Bixin, an natural carotenoid extracted from the seeds of the Bixa orellana has been shown to possess numerous important pharmacological activities. The present study was aimed to investigate the mechanisms of Bixin on carbon tetrachloride… read more here.
Keywords: kidney; tlr4 myd88; fibrosis; bixin ... See more keywords