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   Articles with "tlr4 nlrp3" as a keyword



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Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway

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recommendations! Published in 2022 at "Drug Development Research"

DOI: 10.1002/ddr.21965

Abstract: Tetrahydropalmatine (THP) is the main component of the Chinese medicine Corydalis yanhusuo, which has been reported to alleviate limb ischemia‐reperfusion‐induced acute lung injury (LIR‐ALI). This study aimed to investigate the mechanism underlying the effect of… read more here.

Keywords: lir ali; nlrp3 signaling; expression; polarization ... See more keywords
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Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.

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recommendations! Published in 2021 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2021.110084

Abstract: Inflammation and pyroptosis play a deleterious role in cardiac dysfunction after myocardial infarction (MI). NLRP3/caspase-1 is a well-established axis in pyroptosis and inflammation. In this study, we examined the effects of TN-C on pyroptosis through… read more here.

Keywords: caspase; inactivating tlr4; nlrp3 caspase; pyroptosis ... See more keywords
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N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway.

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recommendations! Published in 2021 at "Experimental eye research"

DOI: 10.1016/j.exer.2021.108595

Abstract: This study aimed to explore the effects of N-acetylserotonin (NAS) on the expression of interleukin-1β (IL-1β) in the retina of retinal ischemia-reperfusion injury (RIRI) rats via the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB)/nod-like receptor… read more here.

Keywords: tak 242; riri; riri nas; group ... See more keywords
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Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.

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recommendations! Published in 2022 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.2c04354

Abstract: Inflammatory bowel disease (IBD) is a global chronic disease with a long duration and repeated relapse. Currently, there is still a lack of effective approaches to prevent IBD. Food-derived oryzanol (ORY) possesses extensive biological activities,… read more here.

Keywords: dss stimulated; tlr4 nlrp3; gut barrier; barrier damage ... See more keywords
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Oleanolic acid derivative isolated fromGardenia jasminoidesvar.radicansalleviates LPS-induced acute kidney injury in mice by reducing oxidative stress and inflammatory responsesviathe TLR4/NF-κB/NLRP3 signaling pathway

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recommendations! Published in 2020 at "New Journal of Chemistry"

DOI: 10.1039/c9nj05294a

Abstract: Acute kidney injury (AKI) is a frequent complication of sepsis with hallmarks including inflammation and oxidative stress. A large amount of oleanolic acid derivatives (TO) have been isolated from Gardenia jasminoides var. radicans, a traditional… read more here.

Keywords: nlrp3 signaling; tlr4 nlrp3; lps induced; oxidative stress ... See more keywords
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Sanziguben polysaccharides improve diabetic nephropathy in mice by regulating gut microbiota to inhibit the TLR4/NF-κB/NLRP3 signalling pathway

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recommendations! Published in 2023 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2023.2174145

Abstract: Abstract Context Sanziguben (SZGB) is an empirical prescription used in traditional Chinese medicine to treat diabetic nephropathy (DN). As an abundant and primarily effective component of SZGB, Sanziguben polysaccharides (SZP) can be digested by flora… read more here.

Keywords: sanziguben; sanziguben polysaccharides; gut microbiota; mice ... See more keywords
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Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2070996

Abstract: ABSTRACT As a multifactorial disease, intervertebral disc degeneration (IVDD) causes many spinal-related diseases, which causes disability in the workforce and heavy social costs all over the world. Recently, Ganoderic Acid A (GAA) has been reported… read more here.

Keywords: activation tlr4; nlrp3 signaling; ganoderic acid; intervertebral disc ... See more keywords
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A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway

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recommendations! Published in 2023 at "mSystems"

DOI: 10.1128/msystems.01127-22

Abstract: Synbiotics can ameliorate liver injury and improve liver function by reducing hepatic inflammation and pyroptosis. Our data indicate that our new Syn not only reverses gut dysbiosis by increasing beneficial bacteria and decreasing lipopolysaccharide (LPS)-bearing… read more here.

Keywords: function; liver; signaling pathway; gut microbiota ... See more keywords
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Isoflurane Attenuates Cerebral Ischaemia–Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/2650693

Abstract: Ischaemic stroke is a severe disease worldwide. Restoration of blood flow after ischaemic stroke leads to cerebral ischaemia–reperfusion injury (CIRI). Various operations, such as cardiac surgery with deep hypothermic circulatory arrest, predictably cause cerebral ischaemia.… read more here.

Keywords: ischaemia; cerebral ischaemia; diabetic mice; injury ... See more keywords
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Tuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study

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recommendations! Published in 2023 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s406483

Abstract: Background Tuo-Min-Ding-Chuan Decoction (TMDCD) is an effective traditional Chinese medicine (TCM) formula granule for allergic asthma (AA). Previous studies proved its effects on controlling airway inflammations, while the specific mechanism was not clear. Methods We… read more here.

Keywords: airway inflammations; pharmacology; mice model; tlr4 nlrp3 ... See more keywords
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Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells

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recommendations! Published in 2020 at "Iranian Journal of Basic Medical Sciences"

DOI: 10.22038/ijbms.2020.44948.10482

Abstract: Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal… read more here.

Keywords: uric acid; intestinal epithelial; epithelial cells; soluble uric ... See more keywords