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   Articles with "tlr4 pathway" as a keyword



Neuroprotective Effects of the Nonsteroidal Anti-inflammatory Drug Celecoxib Against Caspase-1-dependent Pyroptosis Partially by Suppressing the HMGB1/TLR4 Pathway

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recommendations! Published in 2025 at "Cellular and Molecular Neurobiology"

DOI: 10.1007/s10571-025-01615-4

Abstract: This study evaluated the protective effects of celecoxib on epilepsy and explore its potential involvement in regulating pyroptosis and the high mobility group box 1 (HMGB1)/Toll-like receptor 4 (TLR4) signaling pathway. Adult male Sprague–Dawley rats… read more here.

Keywords: tlr4 pathway; celecoxib; pyroptosis; hmgb1 tlr4 ... See more keywords
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Propofol Regulates the TLR4/NF-κB Pathway Through miRNA-155 to Protect Colorectal Cancer Intestinal Barrier.

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recommendations! Published in 2021 at "Inflammation"

DOI: 10.1007/s10753-021-01485-0

Abstract: Surgery for colorectal cancer (CRC) can cause damage to the intestinal mucosal barrier and lead to bacterial invasion. This study mainly analyzed whether propofol (PPF) could protect the intestinal mucosal barrier damage caused by CRC… read more here.

Keywords: barrier; intestinal barrier; mir 155; tlr4 pathway ... See more keywords

Dioscin protects against diabetic nephropathy by inhibiting renal inflammation through TLR4/NF-κB pathway in mice.

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recommendations! Published in 2020 at "Immunobiology"

DOI: 10.1016/j.imbio.2020.151941

Abstract: Diabetic nephropathy (DN) is a chronic kidney disease caused by the long-term loss of renal function, which occurs in 20% - 40% of all diabetes and is also the primary cause of end-stage renal diseases.… read more here.

Keywords: dioscin; tlr4 pathway; diabetic nephropathy; mice ... See more keywords

Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.

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recommendations! Published in 2022 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2022.115001

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), that is associated with a significantly increased risk of colon cancer. As a classic traditional Chinese medicine, Ganluyin (GLY) has a long history… read more here.

Keywords: dss induced; enteric origin; intestinal flora; tlr4 pathway ... See more keywords

Immunomodulatory effect of Celecoxib on HMGB1/TLR4 pathway in a recurrent seizures model in immature rats

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recommendations! Published in 2018 at "Pharmacology Biochemistry and Behavior"

DOI: 10.1016/j.pbb.2018.05.007

Abstract: ABSTRACT Epileptic seizures constitute an important problem in pediatric neurology during the developmental period. The frequency and nosological significance of seizures, as well as their association with epileptogenesis, may be related to underlying mechanisms such… read more here.

Keywords: hmgb1; hmgb1 tlr4; treatment; tlr4 pathway ... See more keywords

LLTH induces white adipose tissue browning via NF κB inhibition in ATM

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-21537-x

Abstract: This study aimed to explore the role of macrophage polarization and TLR4/NF-κB pathway in promoting browning of white adipose tissue through different hypoxic exercises. (1) Fifty obese female rats were selected after 16 weeks of… read more here.

Keywords: white adipose; tlr4 pathway; expression; intervention ... See more keywords

Catalpol relieved angiotensin II-induced blood–brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells

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recommendations! Published in 2022 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2022.2142801

Abstract: Abstract Context Catalpol is a major bioactive constituent of Rehmannia glutinosa Libosch (Scrophulariaceae), a traditional Chinese medicine, which is widely used in multiple diseases, including hypertension. Objectives To explore whether catalpol protects against angiotensin II… read more here.

Keywords: catalpol relieved; blood brain; brain barrier; brain ... See more keywords

Cannabidiol attenuates periodontal inflammation through inhibiting TLR4/NF-κB pathway.

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recommendations! Published in 2023 at "Journal of periodontal research"

DOI: 10.1111/jre.13118

Abstract: BACKGROUND AND OBJECTIVE Periodontitis is a chronic inflammatory disease involving soft and hard tissue destruction in the periodontal region. Cannabidiol (CBD) is a natural compound isolated from cannabis, which has the effect of inhibiting inflammation.… read more here.

Keywords: inflammation; periodontitis; cbd; inhibiting tlr4 ... See more keywords

LTB4 Promotes Acute Lung Injury via Upregulating the PLCε-1/TLR4/NF-κB Pathway in One-Lung Ventilation

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recommendations! Published in 2022 at "Disease Markers"

DOI: 10.1155/2022/1839341

Abstract: Background Mechanical ventilation (MV) can provoke acute lung injury (ALI) by increasing inflammation activation and disrupting the barrier in lung tissues even causing death. However, the inflammation-related molecules and pathways in MV-induced ALI remain largely… read more here.

Keywords: induced ali; plc tlr4; lung; tlr4 ... See more keywords

Butylphthalide Inhibits TLR4/NF-κB Pathway by Upregulation of miR-21 to Have the Neuroprotective Effect

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recommendations! Published in 2022 at "Journal of Healthcare Engineering"

DOI: 10.1155/2022/4687349

Abstract: Stroke is a disease with the highest incidence rate and the highest mortality rate in the world. The study aims to verify the neuroprotective effect of Butylphthalide. The mice were divided into sham group, MCAO… read more here.

Keywords: effect butylphthalide; group; mir; neuroprotective effect ... See more keywords

Protective effects of lipid emulsion on vital organs through the LPS/TLR4 pathway in acute organophosphate poisoning

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recommendations! Published in 2025 at "BMC Pharmacology & Toxicology"

DOI: 10.1186/s40360-025-00904-4

Abstract: Organophosphorus poisoning (OP), a prevalent form of pesticide intoxication, induces severe multiorgan dysfunction. While combined lipid emulsion (ILE) and standard treatment (pralidoxime methiodide & atropine) demonstrate improved clinical outcomes, the therapeutic mechanisms remain elusive. An… read more here.

Keywords: treatment; tlr4 pathway; emulsion; vital organs ... See more keywords