The renoprotective effect of glycyrrhizic acid in insulin-resistant rats exposed to aluminum involves the inhibition of TLR4/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-020-02012-y
Abstract: Aluminum is well recognized as a nephrotoxic agent. Its hazardous effects arise from the high risk of daily exposure. The consumption of fructose also represents a critical health issue that might negatively impact different organs,… read more here.
Keywords: tlr4 signaling; resistant rats; signaling pathway; glycyrrhizic acid ... See more keywords
Cocaine-Mediated Downregulation of miR-124 Activates Microglia by Targeting KLF4 and TLR4 Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0584-5
Abstract: Cocaine is known to activate microglia both in vitro and in vivo. High expression of microglial Toll-like receptors (TLRs) and their downstream signal transducers play critical roles in determining microglial activation status. Emerging reports have… read more here.
Keywords: cocaine; mir 124; tlr4 signaling; cocaine mediated ... See more keywords
The role of TLR4/NF-κB signaling in the radioprotective effects of exogenous Prdx6.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108830
Abstract: Peroxiredoxin 6 (Prdx6) is a bifunctional enzyme with multi-substrate peroxidase and phospholipase activities that is involved in cell redox homeostasis and regulates intracellular processes. Previously, recombinant Prdx6 was shown to exert a radioprotective effect during… read more here.
Keywords: role tlr4; radioprotective effect; prdx6; tlr4 ... See more keywords
Toll-like receptor 4 signaling is required for clusterin-induced tumor necrosis factor-α secretion in macrophage.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.049
Abstract: Clusterin is a secretory glycoprotein that is up-regulated in areas of inflammation and under increased levels of oxidative stress. Previously, we demonstrated that clusterin activates NF-κB, and up-regulates the expression of MMP-9 and TNF-α. In… read more here.
Keywords: secretion; clusterin; macrophage; clusterin induced ... See more keywords
Epac1 regulates TLR4 signaling in the diabetic retinal vasculature.
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DOI: 10.1016/j.cyto.2021.155576
Abstract: Toll-like receptor 4 (TLR4) polymorphisms occur in diabetic patients. Previous work showed that TLR4 is in the retina of diabetic mice, as well as in retinal endothelial cells (REC) and Müller cells. Since we have… read more here.
Keywords: epac1; mice; tlr4 signaling; signaling diabetic ... See more keywords
Resveratrol modulates Toxoplasma gondii infection induced liver injury by intervening in the HMGB1/TLR4/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174497
Abstract: Toxoplasma gondii (T. gondii) is an obligate intracellular parasite that can cause liver diseases in the host, including hepatitis and hepatomegaly. High mobility group box 1box 1 (HMGB1) is the main inflammatory mediator causing cell… read more here.
Keywords: gondii infection; infection; signaling pathway; liver injury ... See more keywords
The cardioprotective effects of icariin on the isoprenaline-induced takotsubo-like rat model: Involvement of reactive oxygen species and the TLR4/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105733
Abstract: INTRODUCTION Takotsubo syndrome (TS) is an acute cardiac syndrome that mimics acute coronary syndrome (ACS) but lacks coronary obstruction and is associated with sudden physical or psychiatric episodes. Several hypotheses have been proposed for the… read more here.
Keywords: reactive oxygen; icariin; oxygen species; signaling pathway ... See more keywords
Antidepressant-like effects of Schisandrin on lipopolysaccharide-induced mice : Gut microbiota, short chain fatty acid and TLR4/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107029
Abstract: Growing evidence shows that gut microbiota and neuroinflammatory responses play a critical role in the pathogenesis of depression. Our previous study demonstrated that schisandrin (SCH) could reduce proinflammatory factors of depressive mice. Therefore, our present… read more here.
Keywords: depressive mice; signaling pathway; gut microbiota; mice ... See more keywords
Safinamide prevents lipopolysaccharide (LPS)-induced inflammation in macrophages by suppressing TLR4/NF-κB signaling.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107712
Abstract: Inflammation is a basal host defense response that eliminates the causes and consequences of infection and tissue injury. Macrophages are the primary immune cells involved in the inflammatory response. When activated by LPS, macrophages release… read more here.
Keywords: prevents lipopolysaccharide; safinamide prevents; inflammation; lipopolysaccharide lps ... See more keywords
TLR4 signaling modulation of PGC1-α mediated mitochondrial biogenesis in the LPS-Chronic mild stress model: Effect of fluoxetine and pentoxiyfylline.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116869
Abstract: AIM The addition of repeated lipopolysaccharide (LPS) to chronic mild stress was recently proposed in our lab as an alternative model of depression, highlighting the possible interaction between stress and immune-inflammatory pathways in predisposing depression.… read more here.
Keywords: pgc1; model; stress; tlr4 signaling ... See more keywords
Vanillin attenuates proinflammatory factors in a tMCAO mouse model via inhibition of TLR4/NF-kB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2022.03.003
Abstract: Vanillin has been reported to reduce hippocampal neuronal death in rat models of global cerebral ischemia. However, the immunoregulatory mechanism of vanillin in ischemic stroke is still unclear. To investigate the role of vanillin in… read more here.
Keywords: mouse model; signaling pathway; tlr4 signaling; vanillin ... See more keywords