LAUSR

TLR4/TRAF6/NOX2 signaling pathway is involved in ventilation-induced lung injury via endoplasmic reticulum stress in murine model.

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0 Published in 2021 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2021.107774

Abstract: In ventilation-induced lung injury (VILI), prolonged nonpathogen-mediated inflammation is triggered as a result of alveolar hyperinflation. In our previous study, we suggested that endoplasmic reticulum (ER) stress-mediated inflammation was involved in VILI, but how ER… read more here.

Keywords: tlr4 traf6; stress; tlr4; lung injury ... See more keywords

Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca2+-NFATc1 signaling pathway

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0 Published in 2019 at "Acta Pharmacologica Sinica"

DOI: 10.1038/s41401-019-0289-6

Abstract: In chronic infectious diseases caused by gram-negative bacteria, such as osteomyelitis, septic arthritis, and periodontitis, osteoclastic activity is enhanced with elevated inflammation, which disturbs the bone homeostasis and results in osteolysis. Lipopolysaccharide (LPS), as a… read more here.

Keywords: lps induced; induced osteoclastogenesis; tlr4 traf6; artesunate attenuates ... See more keywords