Promotion properties of TLR7 in pediatric meningitis via the NF-κB pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-020-09862-4
Abstract: Meningitis outcome is associated with the severity of inflammation in the subarachnoid space and that the outcome can be improved through anti-inflammation. However, a comprehensive understanding of the molecular basis underlying inflammatory responses in meningitis… read more here.
Keywords: meningitis; properties tlr7; tlr7; signaling pathway ... See more keywords
Role of toll-like receptor 7 (TLR7) in voluntary alcohol consumption
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.07.029
Abstract: Abstract Overactivation of neuroimmune signaling has been linked to excessive ethanol consumption. Toll-like receptors (TLRs) are a major component of innate immune signaling and initiate anti- and pro-inflammatory responses via intracellular signal transduction cascades. TLR7… read more here.
Keywords: tlr7; ethanol consumption; role; activation ... See more keywords
Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance
Sign Up to like & getrecommendations! Published in 2022 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.12.033
Abstract: Radioresistance reduces the antitumor efficiency of radiotherapy and further restricts its clinical application, which is mainly caused by the aggravation of immunosuppressive tumor microenvironment (ITM). Especially tumor-associated macrophages (TAMs) usually display the tumor-promoting M2 phenotype… read more here.
Keywords: radioresistance; tlr7; tumor; tumor associated ... See more keywords
Plasmacytoid dendritic cells regulate colitis-associated tumorigenesis by controlling myeloid-derived suppressor cell infiltration.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.08.007
Abstract: Toll-like receptor (TLR)3 and TLR7 are important for stimulating plasmacytoid dendritic cells (pDCs), which secrete type I interferon. Mice deficient for TLR3 and TLR7 (TLR3-/-TLR7-/-) reportedly exhibit deteriorated colitis because of impaired pDCs. However, the… read more here.
Keywords: tlr7; tlr3 tlr7; colon; mice ... See more keywords
Development, Optimization, and In Vivo Validation of New Imidazopyridine Chemotypes as Dual TLR7/TLR9 Antagonists through Activity-Directed Sequential Incorporation of Relevant Structural Subunits.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00386
Abstract: Undesirable activation of endosomal toll-like receptors TLR7 and TLR9 present in specific immune cells in response to host-derived ligands is implicated in several autoimmune diseases and other contexts of autoreactive inflammation, making them important therapeutic… read more here.
Keywords: relevant structural; tlr7; development; structural subunits ... See more keywords
Design and Characterization of Immune-Stimulating Imidazo[4,5-c]quinoline Antibody-Drug Conjugates.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00392
Abstract: Traditional antibody-drug conjugate (ADC) technology has employed tumor-targeting antibodies to selectively deliver ultrapotent cytotoxins to tumor tissue. While this technology has been highly successful, resulting in the FDA approval of over 10 ADCs, the field… read more here.
Keywords: oncology; technology; tlr7; adc technology ... See more keywords
Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00108
Abstract: Immunotherapy has become a powerful clinical strategy for treating infectious diseases and cancer. Synthetic small-molecule toll-like receptor 7 (TLR7) ligands are attractive candidates as immunostimulatory agents for immunotherapy. TLR7 is mainly localized in intracellular endosomal… read more here.
Keywords: small molecule; tlr7 ligand; tlr7; 1v209 man ... See more keywords
Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00977-0
Abstract: Toll-like receptor 7 (TLR7) mediates autoantigen and viral RNA-induced cytokine production. Increased TLR7 expression in human atherosclerotic lesions suggests its involvement in atherogenesis. Here we demonstrated TLR7 expression in macrophages, smooth muscle cells (SMCs), and… read more here.
Keywords: apoe tlr7; tlr7; lesion; mice ... See more keywords
Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1915326116
Abstract: Significance Immunogenic damage-associated molecular patterns (DAMPs), typically released from dying cells, can evoke chronic inflammatory or autoimmune disorders via their activation of innate immune receptors. Since an association of RNA-sensing Toll-like receptor 7 (TLR7) signaling… read more here.
Keywords: mouse models; tlr7; rna; pathogenesis ... See more keywords
Innate immune TLR7 signaling mediates platelet activation and platelet-leukocyte aggregate formation in murine bacterial sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2107627
Abstract: Abstract Thrombocytopenia is a common complication in sepsis and is associated with higher mortality. Activated platelets express CD62P, which facilitates platelet-leukocyte aggregate (PLA) formation and contributes to thrombocytopenia in sepsis. We have reported that thrombocytopenia… read more here.
Keywords: sepsis; tlr7; platelet activation; pla formation ... See more keywords
Molecular cloning, tissue distribution and function analysis of duck TLR7.
Sign Up to like & getrecommendations! Published in 2020 at "Animal biotechnology"
DOI: 10.1080/10495398.2020.1784186
Abstract: Toll-like receptors (TLRs) play an important role in detecting pathogen-associated molecular patterns (PAMPs). Among the TLRs, TLR7 is involved in the recognition of antiviral compounds and single-stranded RNA. This study was designed to explore the… read more here.
Keywords: molecular cloning; tlr7; duck tlr7; duck ... See more keywords