Articles with "tlr7 antagonist" as a keyword



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A Chemical switch for transforming a purine agonist for Toll-like receptor 7 to a clinically relevant antagonist.

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Published in 2020 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.0c00011

Abstract: Toll-like receptor 7 (TLR7) is an established therapeutic target in myriad autoimmune disorders, but no TLR7 antagonist is available for clinical use to date. Herein we report a purine scaffold TLR7 antagonist, first-of-its-kind to our… read more here.

Keywords: toll like; chemical switch; like receptor; clinically relevant ... See more keywords