Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci97333
Abstract: Uncontrolled secretion of type I IFN, as the result of endosomal TLR (i.e., TLR7 and TLR9) signaling in plasmacytoid DCs (pDCs), and abnormal production of autoantibodies by B cells are critical for systemic lupus erythematosus… read more here.
Keywords: murine; mediated autoimmunity; galectin inhibits; tlr7 mediated ... See more keywords
Unraveled role of TLR7-mediated interferon signaling activation in COVID-19
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2025.1658249
Abstract: Emerging evidence underscores the critical role of Toll-like receptor 7 (TLR7)-mediated interferon (IFN) signaling in host defense against viral infections including SARS-CoV-2, through the modulation of both innate and adaptive immunity. However, the specific mechanisms… read more here.
Keywords: mediated interferon; covid; role; activation ... See more keywords