MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.03.008
Abstract: Interferon regulatory factor 7 (IRF7) is a crucial regulator of type I interferons (IFNs) against pathogen infections and plays a significant role in the endosomal Toll-like receptor signaling (namely, TLR7 and TLR9) in plasmacytoid dendritic… read more here.
Keywords: mekk3; activates irf7; tlr7 signaling; irf7 trigger ... See more keywords
Nephropathogenic Infectious Bronchitis Virus Mediates Kidney Injury in Chickens via the TLR7/NF-κB Signaling Axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.865283
Abstract: Nephropathogenic infectious bronchitis virus (NIBV) is one of the most important viral pathogens in the world poultry industry. Here, we used RT–qPCR, WB and immunofluorescence to explore the interaction between NIBV and the host innate… read more here.
Keywords: infectious bronchitis; significantly dpi; nephropathogenic infectious; bronchitis virus ... See more keywords
TLR7 Signaling Shapes and Maintains Antibody Diversity Upon Virus-Like Particle Immunization
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.827256
Abstract: Virus-like particles (VLPs) are used in different marketed vaccines and are able to induce potent antibody responses. The innate pattern recognition receptors TLR7/8 recognize single stranded (ss) RNA naturally packaged into some VLPs and have… read more here.
Keywords: immunization; tlr7; diversity; virus like ... See more keywords