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   Articles with "tlr7 signaling" as a keyword



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MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling.

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recommendations! Published in 2021 at "Molecular immunology"

DOI: 10.1016/j.molimm.2021.03.008

Abstract: Interferon regulatory factor 7 (IRF7) is a crucial regulator of type I interferons (IFNs) against pathogen infections and plays a significant role in the endosomal Toll-like receptor signaling (namely, TLR7 and TLR9) in plasmacytoid dendritic… read more here.

Keywords: mekk3; activates irf7; tlr7 signaling; irf7 trigger ... See more keywords

TLR7 signaling: a central nexus in autoimmunity and cGVHD

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recommendations! Published in 2024 at "Blood Advances"

DOI: 10.1182/bloodadvances.2024012598

Abstract: Conclusive evidence supports the hypothesis that dysregulation in the intrinsic endosomal toll-like receptor (TLR) signaling of antigen-presenting cells, particularly RNA-sensing TLRs, plays a pivotal role in initiating and exacerbating autoimmune conditions, as well as instigating… read more here.

Keywords: tlr7 signaling; ro52; cgvhd; rna ... See more keywords

Nephropathogenic Infectious Bronchitis Virus Mediates Kidney Injury in Chickens via the TLR7/NF-κB Signaling Axis

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recommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2022.865283

Abstract: Nephropathogenic infectious bronchitis virus (NIBV) is one of the most important viral pathogens in the world poultry industry. Here, we used RT–qPCR, WB and immunofluorescence to explore the interaction between NIBV and the host innate… read more here.

Keywords: infectious bronchitis; significantly dpi; nephropathogenic infectious; bronchitis virus ... See more keywords

TLR7 Signaling Shapes and Maintains Antibody Diversity Upon Virus-Like Particle Immunization

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.827256

Abstract: Virus-like particles (VLPs) are used in different marketed vaccines and are able to induce potent antibody responses. The innate pattern recognition receptors TLR7/8 recognize single stranded (ss) RNA naturally packaged into some VLPs and have… read more here.

Keywords: immunization; tlr7; diversity; virus like ... See more keywords