TLR8/TLR7 dysregulation due to a novel TLR8 mutation causes severe autoimmune hemolytic anemia and autoinflammation in identical twins
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26452
Abstract: Our study presents a novel germline c.1715G>T (p.G572V) mutation in the gene encoding Toll‐like receptor 8 (TLR8) causing an autoimmune and autoinflammatory disorder in a family with monozygotic male twins, who suffer from severe autoimmune… read more here.
Keywords: tlr8; severe autoimmune; autoimmune hemolytic; mutation causes ... See more keywords
TLR8 Is a Sensor of RNase T2 Degradation Products
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.11.001
Abstract: TLR8 is among the highest-expressed pattern-recognition receptors in the human myeloid compartment, yet its mode of action is poorly understood. TLR8 engages two distinct ligand binding sites to sense RNA degradation products, although it remains… read more here.
Keywords: tlr8; rnase; rna; tlr8 sensor ... See more keywords
Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.07.004
Abstract: Rational design of drug-like small-molecule ligands based on structural information of proteins remains a significant challenge in chemical biology. In particular, designs targeting protein-protein interfaces have met little success given the dynamic nature of the… read more here.
Keywords: tlr8; molecule; small molecule; rational design ... See more keywords
Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of hypertension"
DOI: 10.1097/hjh.0000000000003410
Abstract: OBJECTIVE Our current study tried to assay the role of long noncoding RNAs (lncRNAs) TLR8-AS1 in regulating preeclampsia. METHODS TLR8-AS1 expression was examined in the clinical placental tissues of preeclampsia patients and the trophoblast cells… read more here.
Keywords: preeclampsia increasing; tlr8; expression; trophoblast cells ... See more keywords
Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aam8458
Abstract: The production of CXCL4 and IFN-α by plasmacytoid DCs in response to TLR8 signaling contributes to skin fibrosis and systemic sclerosis. Plasmacytoid DCs foster fibrosis As potent producers of type I interferon, plasmacytoid dendritic cells… read more here.
Keywords: tlr8; sclerosis; fibrosis; systemic sclerosis ... See more keywords
Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00371
Abstract: During blood-stage malaria, the innate immune system initiates the production of pro-inflammatory cytokines, including IFN-γ, that are critical to host defense and responsible for severe disease. Nonetheless, the innate immune pathways activated during this process… read more here.
Keywords: immune; tlr8; infected red; plasmodium falciparum ... See more keywords
Podocyte Injury Through Interaction Between Tlr8 and Its Endogenous Ligand miR-21 in Obstructed and Its Collateral Kidney
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.606488
Abstract: While chronic kidney disease is prevalent in adults, obstructive nephropathy (ON) has been reported in both young and old patients. In ON, tubulointerstitial lesions (TILs) have been widely investigated, but glomerular lesions (GLs) have been… read more here.
Keywords: tlr8; endogenous ligand; collateral kidney; podocyte injury ... See more keywords