Association of Toll-like receptor 3 and Toll-like receptor 9 single-nucleotide polymorphisms with hepatitis C virus persistence among Egyptians
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3893-8
Abstract: Toll-like receptors (TLRs) give the innate immune system a considerable specificity for a large range of pathogens. TLR3 detects dsRNA of viruses while TLR9 recognizes bacterial and viral unmethylated CpG motifs. This study examined whether… read more here.
Keywords: toll like; infection; tlr9; like receptor ... See more keywords
Inhibition of TLR7 and TLR9 Reduces Human Cholangiocarcinoma Cell Proliferation and Tumor Development
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-021-06973-9
Abstract: Toll-like receptors (TLRs) are key players in innate immunity and modulation of TLR signaling has been demonstrated to profoundly affect proliferation and growth in different types of cancer. However, the role of TLRs in human… read more here.
Keywords: tumor development; tlr9; proliferation; tlr7 tlr9 ... See more keywords
A novel TaqMAMA assay for allelic discrimination of TLR9 rs352140 polymorphism.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2017.01.015
Abstract: TaqMAMA is an allele-specific PCR-based (ASPCR) method that may be suitable for broad and cost-effective genotyping applications in all types of laboratories. There is evidence that interactions between some toll like receptors (TLRs) with viruses… read more here.
Keywords: rs352140 polymorphism; novel taqmama; tlr9; tlr9 rs352140 ... See more keywords
Toll‐like receptor 9 antagonist suppresses humoral immunity in experimental autoimmune myasthenia gravis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.01.005
Abstract: HIGHLIGHTSAblation of TLR9 signalling alleviates EAMG clinical symptoms through disrupting humoral immunity.H154 modulates antibody levels via Tfh and germinal center B cells.Suppressive ODNs of TLR9 pathway regulates B cell function by decreasing the level of… read more here.
Keywords: humoral immunity; toll like; myasthenia gravis; tlr9 ... See more keywords
Toll‐like receptor 9 signaling promotes autophagy and apoptosis via divergent functions of the p38/JNK pathway in human salivary gland cells
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.12.027
Abstract: ABSTRACT Abnormal signaling transduction in salivary gland cells is associated with the pathogenesis of Sjögren's syndrome (SS). Previously, we identified aberrant expression of toll‐like receptor 9 (TLR9) in gland cells of SS patients and mouse… read more here.
Keywords: jnk; apoptosis; tlr9; salivary gland ... See more keywords
Release from Unc93b1 reinforces the compartmentalized activation of select TLRs
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1611-7
Abstract: Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate the recognition of microbial DNA and RNA while limiting the recognition of an organism’s own nucleic acids1. Failure to properly regulate these TLRs… read more here.
Keywords: reinforces compartmentalized; tlr9; tlrs; activation ... See more keywords
Formation of memory assemblies through the DNA-sensing TLR9 pathway
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07220-7
Abstract: As hippocampal neurons respond to diverse types of information1, a subset assembles into microcircuits representing a memory2. Those neurons typically undergo energy-intensive molecular adaptations, occasionally resulting in transient DNA damage3–5. Here we found discrete clusters… read more here.
Keywords: memory; damage; repair; tlr9 ... See more keywords
The significance and role of the receptor and inflammatory factors in acute respiratory distress syndrome
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-20041-6
Abstract: Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by diffuse alveolar damage and severe hypoxemia, with mortality rates remaining high despite advances in supportive care. Cytokine dysregulation and genetic susceptibility are thought to… read more here.
Keywords: respiratory distress; acute respiratory; tnf; tlr2 196 ... See more keywords
Mitochondrial DNA as a Possible Ligand for TLR9 in Irinotecan-induced Small Intestinal Mucositis
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Investigations"
DOI: 10.1080/08820139.2022.2026379
Abstract: ABSTRACT Cancer chemotherapy and radiotherapy may result in mucositis characterized by stem cell damage and inflammation in the gastrointestinal tract. The molecular mechanisms underlying this pathology remain unknown. Based on the assumption that mitochondrial CPG-DNA… read more here.
Keywords: dna; intestinal mucositis; pathology; irinotecan induced ... See more keywords
Role of TLR9 in Oncogenic Virus-Produced Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Viral Immunology"
DOI: 10.1089/vim.2016.0103
Abstract: Abstract Nucleic acid recognition by toll-like receptor 9 (TLR9) initiates signaling pathways that regulate the production of proinflammatory cytokines or type I interferons, as well as many other molecules required to initialize the immune response.… read more here.
Keywords: role tlr9; tlr9 expression; tlr9; recognition ... See more keywords
P4691Chronic blockade of toll-like receptor 9 ameliorated pulmonary arterial hypertension by reducing perivascular inflammation in rats
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz745.1072
Abstract: Perivascular inflammation plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Recent studies have demonstrated that damaged mitochondrial DNA induces sterile inflammation by activating toll-like receptor (TLR)9 in spontaneous hypertensive rats. However,… read more here.
Keywords: arterial hypertension; inflammation; tlr9; pulmonary arterial ... See more keywords