RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202105391
Abstract: The subcellular localization and intracellular trafficking of Toll-like receptors (TLRs) critically regulate TLRs-mediated antimicrobial immunity and autoimmunity. Here, it is demonstrated that the E3 ubiquitin ligase RNF115 inhibits the post-endoplasmic reticulum (ER) trafficking of TLRs… read more here.
Keywords: rab1a rab13; trafficking tlrs; rnf115; post ... See more keywords
The TLR‐chaperone CNPY3 is a critical regulator of NLRP3‐inflammasome activation
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149612
Abstract: TLRs mediate the recognition of microbial and endogenous insults to orchestrate the inflammatory response. TLRs localize to the plasma membrane or endomembranes, depending on the member, and rely critically on ER‐resident chaperones to mature and… read more here.
Keywords: role cnpy3; cnpy3; inflammasome activation; tlrs ... See more keywords
Intracellular TLRs of Mast Cells in Innate and Acquired Immunity.
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DOI: 10.1007/164_2021_540
Abstract: Mast cells (MCs) distribute to interface tissues with environment, such as skin, airway, and gut mucosa, thereby functioning as the sentinel against invading allergens and pathogens. To respond to and exclude these external substances promptly,… read more here.
Keywords: mcs; immunity; intracellular tlrs; mast cells ... See more keywords
TLR10 and Its Role in Immunity.
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DOI: 10.1007/164_2021_541
Abstract: Toll like receptors (TLRs) are the most studied pattern recognition receptors (PRRs) as they connect the innate to the acquired immune response. To date, there are ten human TLRs which are expressed either on the… read more here.
Keywords: tlr10 role; immunity; role immunity; tlrs ... See more keywords
Attenuation of the Induction of TLRs 2 and 4 Mitigates Inflammation and Promotes Neurological Recovery After Focal Cerebral Ischemia
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DOI: 10.1007/s12975-020-00884-z
Abstract: The intense inflammatory response triggered in the brain after focal cerebral ischemia is detrimental. Recently, we showed that the suppression of toll-like receptors (TLRs) 2 and 4 attenuates infarct size and reduces the expression of… read more here.
Keywords: recovery; cerebral ischemia; reperfusion; tlrs ... See more keywords
Anti-influenza A virus mechanism of three representative compounds from Flos Trollii via TLRs signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112634
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Flos Trollii is the dried flowers of Trollius chinensis. It has been used as a traditional herbal medicine for the treatment of upper respiratory tract infection, tonsillitis and pharyngitis in China for a… read more here.
Keywords: medicine; flos trollii; representative compounds; tlrs ... See more keywords
Release from Unc93b1 reinforces the compartmentalized activation of select TLRs
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DOI: 10.1038/s41586-019-1611-7
Abstract: Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate the recognition of microbial DNA and RNA while limiting the recognition of an organism’s own nucleic acids1. Failure to properly regulate these TLRs… read more here.
Keywords: reinforces compartmentalized; tlr9; tlrs; activation ... See more keywords
Evolutionary History of the Toll-Like Receptor Gene Family across Vertebrates
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evz266
Abstract: Abstract Adaptation to a wide range of pathogenic environments is a major aspect of the ecological adaptations of vertebrates during evolution. Toll-like receptors (TLRs) are ancient membrane-bound sensors in animals and are best known for… read more here.
Keywords: toll like; tlrs; gene family; vertebrate ... See more keywords
Genetic characterizations of Toll-like receptors in the brown rat and their associations with pathogen infections.
Sign Up to like & getrecommendations! Published in 2021 at "Integrative zoology"
DOI: 10.1111/1749-4877.12555
Abstract: Toll-like receptors (TLRs) are important initiators of innate immune responses that target host-pathogen interactions. However, further research into the molecular characteristics of TLRs in wild populations is required, as well as how TLRs genetically influenced… read more here.
Keywords: toll like; brown rat; pathogen infections; tlrs ... See more keywords
Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products
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DOI: 10.1155/2017/2086840
Abstract: TLRs recognize a broad spectrum of microorganism molecules, triggering a variety of cellular responses. Among them, phagocytosis is a critical process for host defense. Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcγR-mediated… read more here.
Keywords: mediated phagocytosis; phagocytosis; igg; tlr3 ... See more keywords
Computational molecular characterization of p53 and Human TLRs interactions.
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DOI: 10.14715/cmb/2021.67.5.1
Abstract: Toll-like receptors (TLRs) are one of the major sensors to regulate innate immunity. It is present in inactive form within immune cells. However, after recognizing the conserved region of the foreign body, it gets activated… read more here.
Keywords: toll like; interaction p53; p53; tlrs ... See more keywords