Regulation of behaviour by the nuclear receptor TLX
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1111/gbb.12357
Abstract: The orphan nuclear receptor Tlx (Nr2e1) is a key regulator of both embryonic and adult hippocampal neurogenesis. Several different mouse models have been developed which target Tlx in vivo including spontaneous deletion models (from birth)… read more here.
Keywords: receptor tlx; regulation behaviour; tlx; nuclear receptor ... See more keywords
TLX, an orphan nuclear receptor with emerging roles in physiology and disease.
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinology"
DOI: 10.1210/endocr/bqab184
Abstract: TLX (NR2E1), an orphan member of the nuclear receptor superfamily, is a transcription factor that has been described to be generally repressive in nature. It has been implicated in several aspects of physiology and disease.… read more here.
Keywords: physiology; tlx; nuclear receptor; physiology disease ... See more keywords
Validation of the Raw National Aeronautics and Space Administration Task Load Index (NASA-TLX) Questionnaire to Assess Perceived Workload in Patient Monitoring Tasks: Pooled Analysis Study Using Mixed Models
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Internet Research"
DOI: 10.2196/19472
Abstract: Background Patient monitoring is indispensable in any operating room to follow the patient’s current health state based on measured physiological parameters. Reducing workload helps to free cognitive resources and thus influences human performance, which ultimately… read more here.
Keywords: aeronautics; patient monitoring; tlx; raw nasa ... See more keywords
Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor
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DOI: 10.3390/molecules23112967
Abstract: Orphan nuclear receptor TLX (NR2E1) plays a critical role in the regulation of neural stem cells (NSC) as well as in the development of NSC-derived brain tumors. In the last years, new data have emerged… read more here.
Keywords: small molecule; tlx; molecule inhibitors; transcriptional activity ... See more keywords