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   Articles with "tm4sf5" as a keyword



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TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.110018

Abstract: Chronic injury to hepatocytes results in inflammation, steatohepatitis, fibrosis, and nonalcoholic fatty liver disease (NAFLD). The tetraspanin TM4SF5 is implicated in fibrosis and cancer. We investigate the role of TM4SF5 in communication between hepatocytes and… read more here.

Keywords: tm4sf5; tm4sf5 dependent; hepatocytes macrophages; dependent crosstalk ... See more keywords

Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.

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recommendations! Published in 2019 at "Cell metabolism"

DOI: 10.1016/j.cmet.2019.03.005

Abstract: The mechanistic target of rapamycin complex (mTORC1) is a signaling hub on the lysosome surface, responding to lysosomal amino acids. Although arginine is metabolically important, the physiological arginine sensor that activates mTOR remains unclear. Here,… read more here.

Keywords: six family; tm4sf5; mtorc1 signaling; transmembrane six ... See more keywords

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage

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recommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-024-02106-6

Abstract: Dynamic communication between hepatocytes and the environment is critical in hepatocellular carcinoma (HCC) development. Clinical immunotherapy against HCC is currently unsatisfactory and needs more systemic considerations, including the identification of new biomarkers and immune checkpoints.… read more here.

Keywords: isoxazole; slamf7; tm4sf5; hcc ... See more keywords

Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity

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recommendations! Published in 2017 at "Theranostics"

DOI: 10.7150/thno.15629

Abstract: The transmembrane four L6 family member 5 (TM4SF5) protein is a novel molecular target for the prevention and treatment of hepatocellular carcinoma. TM4SF5 is highly expressed in liver, colon, esophageal, and pancreatic cancers and is… read more here.

Keywords: cancer; ab27 ab79; tm4sf5; cell mediated ... See more keywords