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   Articles with "tmao" as a keyword



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No Change in the Age‐Adjusted Incidence of Parkinson's Disease in Finland for More Than 25 Years

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recommendations! Published in 2020 at "Movement Disorders"

DOI: 10.1002/mds.28250

Abstract: PD will likely become 2 to 3 times as common as it is now during the next 2 decades. Aging of the population is the FIG. 1. Plasma TMAO levels in controls and patients with… read more here.

Keywords: tmao; disease; plasma tmao; tmao levels ... See more keywords

Trimethylamine N‐oxide (TMAO) doubly locks the hydrophobic core and surfaces of protein against desiccation stress

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recommendations! Published in 2024 at "Protein Science"

DOI: 10.1002/pro.5107

Abstract: Interactions between proteins and osmolytes are ubiquitous within cells, assisting in response to environmental stresses. However, our understanding of protein–osmolyte interactions underlying desiccation tolerance is limited. Here, we employ solid‐state NMR (ssNMR) to derive information… read more here.

Keywords: desiccation; trimethylamine oxide; hydrophobic core; protein ... See more keywords

Perilla frutescens L. alleviates trimethylamine N‐oxide–induced apoptosis in the renal tubule by regulating ASK1‐JNK phosphorylation

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7684

Abstract: Trimethylamine N‐oxide (TMAO) is associated with overall mortality in patients with chronic kidney disease (CKD). Previous findings suggest that P. frutescens (L.) can alleviate renal injury, but its effects and mechanisms underlying alleviation of TMAO‐induced… read more here.

Keywords: apoptosis; jnk phosphorylation; jnk; tmao ... See more keywords
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Amelioration of TMAO through probiotics and its potential role in atherosclerosis

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recommendations! Published in 2019 at "Applied Microbiology and Biotechnology"

DOI: 10.1007/s00253-019-10142-4

Abstract: Atherosclerosis is a major cause of mortalities and morbidities worldwide. It is associated with hyperlipidemia and inflammation, and become chronic by triggering metabolites in different metabolic pathways. Disturbance in the human gut microbiota is now… read more here.

Keywords: tmao probiotics; tmao; probiotics potential; potential role ... See more keywords

Circulating trimethylamine N-oxide levels following fish or seafood consumption

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recommendations! Published in 2022 at "European Journal of Nutrition"

DOI: 10.1007/s00394-022-02803-4

Abstract: Some species of fish and seafood are high in trimethylamine N-oxide (TMAO), which accumulates in muscle where it protects against pressure and cold. Trimethylamine (TMA), the metabolic precursor to TMAO, is formed in fish during… read more here.

Keywords: tmao levels; fish seafood; tmao; seafood consumption ... See more keywords

What is the hydrophobic interaction contribution to the stabilization of micro-hydrated complexes of trimethylamine oxide (TMAO)? A joint DFT-D, QTAIM, and MESP study

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recommendations! Published in 2019 at "Journal of Molecular Modeling"

DOI: 10.1007/s00894-019-4217-y

Abstract: Micro-hydrated trimethylamine oxide (TMAO) has been investigated using a range-separated-hybrid functional including empirical dispersion correction. Electrophilic and nucleophilic sites on TMAO and water clusters have been identified using the molecular electrostatic potential (MESP). The nature… read more here.

Keywords: micro hydrated; water; tmao; hydrated complexes ... See more keywords

Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD

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recommendations! Published in 2025 at "Cell Biology and Toxicology"

DOI: 10.1007/s10565-025-10060-4

Abstract: As a primary contributor to end-stage renal disease, diabetic kidney disease (DKD) is characterized by metabolic and inflammatory disturbances. Emerging evidence highlights the gut microbiota's contribution to DKD through metabolite interactions. This study investigates the… read more here.

Keywords: prss3; kidney; gut microbiota; damage ... See more keywords

Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases.

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recommendations! Published in 2021 at "Cardiovascular toxicology"

DOI: 10.1007/s12012-021-09656-z

Abstract: Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of choline, betaine or L-carnitine and could be further converted to Trimethylamine-N-oxide (TMAO) in the liver. As the function of gut microbiota and… read more here.

Keywords: trimethylamine oxide; tmao; tma tmao; cardiovascular diseases ... See more keywords

Protective Role of (-)-Epicatechin on Trimethylamine-N-Oxide (TMAO)-Induced Cardiac Hypertrophy via SP1/SIRT1/SUMO1 Signaling Pathway

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recommendations! Published in 2024 at "Cardiovascular Toxicology"

DOI: 10.1007/s12012-024-09932-8

Abstract: (-)-Epicatechin (EPI) is beneficial for cardiovascular health. Trimethylamine N-oxide (TMAO), a gut microbe-derived food metabolite, is strongly associated with the risk of cardiovascular diseases. However, the effects and underlying mechanisms of EPI on TMAO-induced cardiac… read more here.

Keywords: cardiac hypertrophy; hypertrophy; sp1 sirt1; tmao induced ... See more keywords

Gut microbial metabolite TMAO contributes to renal dysfunction in a mouse model of diet-induced obesity.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.09.108

Abstract: Emerging evidence shows that obesity induces renal injury and is an independent risk factor for the development of chronic kidney disease (CKD), even without diabetes or hyperglycemia. Although multiple metabolic factors have been suggested to… read more here.

Keywords: obesity; dysfunction; tmao; contributes renal ... See more keywords

Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways

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recommendations! Published in 2019 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2019.03.066

Abstract: Background We previously demonstrated the gut microbes-derived metabolite trimethylamine N-oxide (TMAO) could activate the atrial autonomic ganglion plexus and promote atrial arrhythmia. The cardiac sympathetic nervous system (CSNS) play important roles in modulating ventricular arrhythmia… read more here.

Keywords: arrhythmia; nervous system; tmao; derived metabolite ... See more keywords