No Change in the Age‐Adjusted Incidence of Parkinson's Disease in Finland for More Than 25 Years
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.28250
Abstract: PD will likely become 2 to 3 times as common as it is now during the next 2 decades. Aging of the population is the FIG. 1. Plasma TMAO levels in controls and patients with… read more here.
Keywords: tmao; disease; plasma tmao; tmao levels ... See more keywords
Perilla frutescens L. alleviates trimethylamine N‐oxide–induced apoptosis in the renal tubule by regulating ASK1‐JNK phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7684
Abstract: Trimethylamine N‐oxide (TMAO) is associated with overall mortality in patients with chronic kidney disease (CKD). Previous findings suggest that P. frutescens (L.) can alleviate renal injury, but its effects and mechanisms underlying alleviation of TMAO‐induced… read more here.
Keywords: apoptosis; jnk phosphorylation; jnk; tmao ... See more keywords
Amelioration of TMAO through probiotics and its potential role in atherosclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10142-4
Abstract: Atherosclerosis is a major cause of mortalities and morbidities worldwide. It is associated with hyperlipidemia and inflammation, and become chronic by triggering metabolites in different metabolic pathways. Disturbance in the human gut microbiota is now… read more here.
Keywords: tmao probiotics; tmao; probiotics potential; potential role ... See more keywords
Circulating trimethylamine N-oxide levels following fish or seafood consumption
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Nutrition"
DOI: 10.1007/s00394-022-02803-4
Abstract: Some species of fish and seafood are high in trimethylamine N-oxide (TMAO), which accumulates in muscle where it protects against pressure and cold. Trimethylamine (TMA), the metabolic precursor to TMAO, is formed in fish during… read more here.
Keywords: tmao levels; fish seafood; tmao; seafood consumption ... See more keywords
What is the hydrophobic interaction contribution to the stabilization of micro-hydrated complexes of trimethylamine oxide (TMAO)? A joint DFT-D, QTAIM, and MESP study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4217-y
Abstract: Micro-hydrated trimethylamine oxide (TMAO) has been investigated using a range-separated-hybrid functional including empirical dispersion correction. Electrophilic and nucleophilic sites on TMAO and water clusters have been identified using the molecular electrostatic potential (MESP). The nature… read more here.
Keywords: micro hydrated; water; tmao; hydrated complexes ... See more keywords
Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular toxicology"
DOI: 10.1007/s12012-021-09656-z
Abstract: Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of choline, betaine or L-carnitine and could be further converted to Trimethylamine-N-oxide (TMAO) in the liver. As the function of gut microbiota and… read more here.
Keywords: trimethylamine oxide; tmao; tma tmao; cardiovascular diseases ... See more keywords
Gut microbial metabolite TMAO contributes to renal dysfunction in a mouse model of diet-induced obesity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.108
Abstract: Emerging evidence shows that obesity induces renal injury and is an independent risk factor for the development of chronic kidney disease (CKD), even without diabetes or hyperglycemia. Although multiple metabolic factors have been suggested to… read more here.
Keywords: obesity; dysfunction; tmao; contributes renal ... See more keywords
Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.03.066
Abstract: Background We previously demonstrated the gut microbes-derived metabolite trimethylamine N-oxide (TMAO) could activate the atrial autonomic ganglion plexus and promote atrial arrhythmia. The cardiac sympathetic nervous system (CSNS) play important roles in modulating ventricular arrhythmia… read more here.
Keywords: arrhythmia; nervous system; tmao; derived metabolite ... See more keywords
Increased plasma trimethylamine-N-oxide is associated with incident atrial fibrillation.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.04.128
Abstract: BACKGROUND Plasma trimethylamine-N-oxide (TMAO) is associated with cardiovascular disease; however specific relationships with cardiac arrhythmias are unknown. We evaluated the association between plasma TMAO and incident atrial fibrillation (AF). METHODS Risk associations were explored among… read more here.
Keywords: atrial fibrillation; risk; tmao; incident atrial ... See more keywords
An efficient study to reach physiological temperature with poly(N-isopropylacrylamide) in presence of two differently behaving additives.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2018.11.081
Abstract: HYPOTHESIS The new findings in the field of polymeric materials expanding their applications in improving the quality of health care are of primary concern. Undoubtedly, the alteration in surface properties of polymeric materials on addition… read more here.
Keywords: temperature; pnipam; tmao; poly isopropylacrylamide ... See more keywords
Ion solvation scenario in an aqueous solution mixture of counteracting osmolytes: Urea and trimethylamine-N-oxide (TMAO)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2019.111467
Abstract: Abstract In this study, we investigate that how the ion solvation scenario of different charged species (Na+, K+, Cl−, Cl0, NH4+, NMe4+ and CH3COO−) in highly concentrated urea solution (8 M) gets modified on addition of… read more here.
Keywords: water; hydrogen; ion solvation; ion ... See more keywords