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Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1372
Abstract: Purpose: Microsatellite instability (MSI) and high tumor mutation burden (TMB-High) are promising pan-tumor biomarkers used to select patients for treatment with immune checkpoint blockade; however, real-time sequencing of unresectable or metastatic solid tumors is often…
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Keywords:
tmb high;
cancer;
high tumor;
microsatellite instability ... See more keywords
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Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-6670
Abstract: Cancer immunotherapy with checkpoint blockade has improved survival and outcomes in melanoma, but still a majority of patients do not respond. Both high tumor mutation burden (TMB) and high T cell infiltration have been associated…
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Keywords:
melanoma;
signals tumor;
response;
tmb high ... See more keywords
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Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.2617
Abstract: 2617 Background: ICI benefit certain patients (pts) with various malignancies and discovering biomarkers for response is an active research field. Recently, higher TMB (top 20% in each histology) based on nonsynonymous single nucleotide variants from…
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Keywords:
tmb high;
histology;
cancer;
fsindel ... See more keywords