TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy
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DOI: 10.26508/lsa.202201478
Abstract: TMBIM5 deficiency reduces mitochondrial K+/H+ exchange. Mutation of the channel pore in mice destabilizes the protein and results in increased embryonic lethality and a skeletal myopathy. Ion fluxes across the inner mitochondrial membrane control mitochondrial… read more here.
Keywords: mitochondrial matrix; function; loss; ion ... See more keywords