Articles with "tmdd" as a keyword



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Target-mediated drug disposition model for drugs with two binding sites that bind to a target with one binding site

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Published in 2017 at "Journal of Pharmacokinetics and Pharmacodynamics"

DOI: 10.1007/s10928-017-9533-1

Abstract: The paper extended the TMDD model to drugs with two identical binding sites (2-1 TMDD). The quasi-steady-state (2-1 QSS), quasi-equilibrium (2-1 QE), irreversible binding (2-1 IB), and Michaelis–Menten (2-1 MM) approximations of the model were… read more here.

Keywords: target; drug; model; binding sites ... See more keywords
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Target-mediated exposure enhancement: a previously unexplored limit of TMDD

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Published in 2020 at "Journal of Pharmacokinetics and Pharmacodynamics"

DOI: 10.1007/s10928-020-09693-1

Abstract: Target-mediated drug disposition (TMDD) is often observed for targeted therapeutics, and manifests as decreases in clearance and volume of distribution with increasing dose as a result of saturable, high affinity target binding. In the present… read more here.

Keywords: previously unexplored; exposure enhancement; mediated exposure; target ... See more keywords