Transmembrane protein 119 is neither a specific nor a reliable marker for microglia
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24164
Abstract: Microglia are the resident innate immune cells of the central nervous system (CNS) parenchyma. To determine the impact of microglia on disease development and progression in neurodegenerative and neuroinflammatory diseases, it is essential to distinguish… read more here.
Keywords: neither specific; marker; tmem119; protein 119 ... See more keywords
Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Baló's disease and neuromyelitis optica spectrum disorders
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DOI: 10.1111/bpa.12898
Abstract: TMEM119 and purinergic receptor P2Y12 (P2RY12), which are not expressed by recruited peripheral blood macrophages, are proposed to discriminate microglia from macrophages. Therefore, we investigated the distribution patterns of microglia and macrophages in 10 concentric… read more here.
Keywords: concentric lesions; disease; neuromyelitis optica; bal disease ... See more keywords
Protein Expression of the Microglial Marker Tmem119 Decreases in Association With Morphological Changes and Location in a Mouse Model of Traumatic Brain Injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.820127
Abstract: The activation of microglia and the infiltration of macrophages are hallmarks of neuroinflammation after acute brain injuries, including traumatic brain injury (TBI). The two myeloid populations share many features in the post-injury inflammatory response, thus,… read more here.
Keywords: expression; brain injury; tmem119; protein ... See more keywords
Identification and Characterization of TMEM119-Positive Cells in the Postnatal and Adult Murine Cochlea
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DOI: 10.3390/brainsci13030516
Abstract: Transmembrane protein 119 (TMEM119) is expressed in a subset of resident macrophage cells of the brain and was proposed as a marker for native brain microglia. The presence of cells expressing TMEM119 in the cochlea… read more here.
Keywords: postnatal adult; tmem119; adult murine; cochlea ... See more keywords