Drugs that inhibit TMEM16 proteins block SARS-CoV-2 Spike-induced syncytia.
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DOI: 10.1038/s41586-021-03491-6
Abstract: COVID-19 is a disease with unique characteristics including lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar oedema4. The pathological substrate for these findings remains… read more here.
Keywords: syncytia; cov spike; inhibit tmem16; drugs inhibit ... See more keywords
Divalent Cation Modulation of Ion Permeation in TMEM16 Proteins
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DOI: 10.3390/ijms22042209
Abstract: Intracellular divalent cations control the molecular function of transmembrane protein 16 (TMEM16) family members. Both anion channels (such as TMEM16A) and phospholipid scramblases (such as TMEM16F) in this family are activated by intracellular Ca2+ in… read more here.
Keywords: cation; divalent cation; divalent cations; ion ... See more keywords