TMEM16A/ANO1 suppression improves response to antibody‐mediated targeted therapy of EGFR and HER2/ERBB2
Sign Up to like & getrecommendations! Published in 2017 at "Genes"
DOI: 10.1002/gcc.22450
Abstract: TMEM16A, a Ca2+‐activated Cl− channel, contributes to tumor growth in breast cancer and head and neck squamous cell carcinoma (HNSCC). Here, we investigated whether TMEM16A influences the response to EGFR/HER family‐targeting biological therapies. Inhibition of… read more here.
Keywords: egfr her2; improves response; tmem16a; antibody ... See more keywords
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2022.102206
Abstract: Cystic fibrosis (CF) is a multi-organ genetic disease caused by loss of function of CFTR, a cAMP-regulated chloride channel expressed in epithelial cells. In airway epithelia, CFTR-dependent chloride secretion is required to humidify mucosal surface… read more here.
Keywords: cystic fibrosis; tmem16a; tmem16a ano1; ano1 therapeutic ... See more keywords
Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174340
Abstract: The transmembrane member 16A (TMEM16A)-encoded Ca2+-activated Cl- channel (CaCC) is expressed in interstitial cells of Cajal (ICCs) and involved in the generation of the slow-wave currents of gastrointestinal (GI) smooth muscles. TMEM16A modulators have been… read more here.
Keywords: inhibitory effects; tmem16a; evodiamine rutecarpine; tmem16a inhibitors ... See more keywords
Voltage-Dependent Protonation of the Calcium Pocket Enable Activation of the Calcium-Activated Chloride Channel Anoctamin-1 (TMEM16A)
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62860-9
Abstract: Anoctamin-1 (ANO1 or TMEM16A) is a homo-dimeric Ca 2+ -activated Cl − channel responsible for essential physiological processes. Each monomer harbours a pore and a Ca 2+ -binding pocket; the voltage-dependent binding of two intracellular… read more here.
Keywords: voltage; dependent protonation; voltage dependent; tmem16a ... See more keywords
Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2023.2165067
Abstract: TMEM16A regulator is an important tool to study the physiological functions and pathogenesis related to TMEM16A. In the present study, trans-ε-viniferin (TV) was identified as a TMEM16A inhibitor with inhibitory activity against TMEM16A mediated Cl-… read more here.
Keywords: intestinal smooth; trans viniferin; muscle contraction; inhibitor ... See more keywords
Endothelial cell TMEM16A channels regulate arterial contractility and blood pressure
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5726735
Abstract: Endothelial cells (ECs) are electrically coupled to arterial smooth muscle cells in the vascular wall and can modulate their contractility through direct control of membrane potential and via the production of several vasoactive substances. ECs… read more here.
Keywords: tmem16a channels; contractility; physiology; tmem16a ... See more keywords
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.201908-1641oc
Abstract: Rationale: Enhancing non–CFTR (cystic fibrosis transmembrane conductance regulator)-mediated anion secretion is an attractive therapeutic approach for the treatment of cystic fibrosis (CF) and other mucoobstructive diseases. Objectives: To determine the effects of TMEM16A potentiation on… read more here.
Keywords: tmem16a; cystic fibrosis; approach treatment; secretion ... See more keywords
TMEM16A chloride channel does not drive mucus production
Sign Up to like & getrecommendations! Published in 2019 at "Life Science Alliance"
DOI: 10.26508/lsa.201900462
Abstract: Despite being essential for airway hydration, TMEM16A is not required for mucus (MUC5AC) production. Cell proliferation is the main driver for TMEM16A up-regulation during inflammation. Airway mucus obstruction is the main cause of morbidity in… read more here.
Keywords: production; mucus production; proliferation; muc5ac ... See more keywords
TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00360
Abstract: The inflammatory response plays a pivotal role in Blood–Brain Barrier (BBB) destruction following ischemic brain injury. Enhanced leukocyte adhesion to vascular endothelial cells is an essential event in the inflammatory process. TMEM16A, a newly discovered… read more here.
Keywords: blood brain; ischemic stroke; tmem16a; brain barrier ... See more keywords
Downregulation of Ca2+-Activated Cl− Channel TMEM16A Mediated by Angiotensin II in Cirrhotic Portal Hypertensive Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.831311
Abstract: Portal hypertension is defined as an increased pressure in the portal venous system and occurs as a major complication in chronic liver diseases. The pathological mechanism underlying the pathogenesis and development of portal hypertension has… read more here.
Keywords: tmem16a; downregulation; mice; portal hypertension ... See more keywords
TMEM16A Plays an Insignificant Role in Myocardium Remodeling but May Promote Angiogenesis of Heart During Pressure-overload
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.897619
Abstract: Background: Cardiac hypertrophy (CH) occurs with an increase in myocardium mass as an adaptive compensation to increased stress. Prolonged CH causes decompensated heart failure (HF). Enhanced angiogenesis by vascular endothelial growth factor (VEGF) is observed… read more here.
Keywords: migration angiogenesis; tmem16a; heart; expressed ecs ... See more keywords