Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.001
Abstract: Neuronal Ca2+ entry elicited by electrical activity contributes to information coding via activation of K+ and Cl- channels. While Ca2+-dependent K+ channels have been extensively studied, the molecular identity and role of Ca2+-activated Cl- channels… read more here.
Keywords: motor resistance; motoneuron tmem16f; spinal motoneuron; motor ... See more keywords
Single-molecule analysis of phospholipid scrambling by TMEM16F
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1717956115
Abstract: Significance Membrane proteins that translocate various compounds across biological membranes play important roles in maintaining intracellular homeostasis in cells. Scramblases are membrane proteins that translocate phospholipids between the inner and outer leaflets of the plasma… read more here.
Keywords: molecule; single molecule; scramblase; phospholipid scrambling ... See more keywords
ENDOTHELIAL-SPECIFIC KNOCKOUT OF THE SCRAMBLASE TMEM16F IMPAIRS IN VIVO CLOT FORMATION
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DOI: 10.1097/shk.0000000000002553
Abstract: ABSTRACT Objective: Loss of function of the phospholipid scramblase (PLS) TMEM16F results in Scott syndrome, a hereditary bleeding disorder generally attributed to intrinsic platelet dysfunction. The role of TMEM16F in endothelial cells, however, is not… read more here.
Keywords: endothelial specific; time; bleeding; tmem16f ... See more keywords
TMEM16F regulates pathologic α‐synuclein secretion and spread in cellular and mouse models of Parkinson's disease
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DOI: 10.1111/acel.14387
Abstract: One of the main hallmarks of Parkinson's disease (PD) pathology is the spread of the aggregate‐prone protein α‐synuclein (α‐syn), which can be detected in the plasma and cerebrospinal fluid of patients as well as in… read more here.
Keywords: pathology; tmem16f; spread; secretion ... See more keywords
Regulation and Function of TMEM16F in Renal Podocytes
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DOI: 10.3390/ijms19061798
Abstract: The Ca2+-activated phospholipid scramblase and ion channel TMEM16F is expressed in podocytes of renal glomeruli. Podocytes are specialized cells that form interdigitating foot processes as an essential component of the glomerular filter. These cells, which… read more here.
Keywords: ca2 activated; ca2; tmem16f; regulation function ... See more keywords
Characterization of TMEM16F-Specific Affibodies and Their Cellular Effects
Sign Up to like & getrecommendations! Published in 2025 at "Membranes"
DOI: 10.3390/membranes15090255
Abstract: The TMEM16 (Anoctamin) family comprises a group of transmembrane proteins involved in diverse physiological processes, including ion transport and phospholipid scrambling. TMEM16F (Anoctamin 6), a phospholipid scramblase and nonselective ion channel, plays a central role… read more here.
Keywords: tmem16f specific; specific affibodies; tmem16f; characterization tmem16f ... See more keywords