TMEM2 Modulates ER Stress in a Non-canonical Manner.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.11.008
Abstract: Cells utilize multiple mechanisms to support endoplasmic reticulum (ER) function. The unfolded protein response, UPRER, is engaged during proteotoxic challenges to either mitigate ER stress or promote apoptosis. In a CRISPR-based genetic screen, Schinzel et al.… read more here.
Keywords: tmem2 modulates; modulates stress; tmem2; non canonical ... See more keywords
Structure of the transmembrane protein 2 (TMEM2) ectodomain and its lack of hyaluronidase activity
Sign Up to like & getrecommendations! Published in 2023 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.18937.1
Abstract: Background: Hyaluronic acid (HA) is a major polysaccharide component of the extracellular matrix. HA has essential functions in tissue architecture and the regulation of cell behaviour. HA turnover needs to be finely balanced. Increased HA… read more here.
Keywords: hyaluronidase activity; tmem2; transmembrane protein; structure ... See more keywords
Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity
Sign Up to like & getrecommendations! Published in 2023 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.18937.2
Abstract: Background: Hyaluronic acid (HA) is a major polysaccharide component of the extracellular matrix. HA has essential functions in tissue architecture and the regulation of cell behaviour. HA turnover needs to be finely balanced. Increased HA… read more here.
Keywords: hyaluronidase activity; tmem2; transmembrane protein; structure ... See more keywords