TMET-36. INCREASED METHIONINE CYCLE DRIVES PYRIMIDINE METABOLISM IN LETHAL PEDIATRIC EPENDYMOMAS
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DOI: 10.1093/neuonc/noae165.1174
Abstract: Supratentorial ependymomas (ST-EPN) are pediatric brain tumors found in the cerebral hemisphere, driven by the oncogenic fusion of ZFTA with RELA. Other than surgery and radiotherapy, these tumors do not have effective therapeutic options. Recurrent… read more here.
Keywords: tmet increased; pyrimidine metabolism; methionine cycle; metabolism ... See more keywords