Efficient Delivery of siRNA via Tetrahedral Framework Nucleic Acids: Inflammation Attenuation and Matrix Regeneration in Temporomandibular Joint Osteoarthritis.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c11089
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is the most common and severe subtype of temporomandibular disease characterized by inflammation and cartilage matrix degradation. Compared with traditional conservative treatment, small interfering RNAs (siRNAs) have emerged as a more… read more here.
Keywords: temporomandibular joint; tetrahedral framework; tmjoa; sirna ... See more keywords
Sexual dimorphism of estrogen-sensitized synoviocytes contributes to gender difference in temporomandibular joint osteoarthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Oral diseases"
DOI: 10.1111/odi.12905
Abstract: OBJECTIVES Temporomandibular joint osteoarthritis (TMJOA) is approximately twice as prevalent in women than in men. Synoviocytes are believed to play a critical role in joint inflammation. However, it is unknown whether synoviocytes from different genders… read more here.
Keywords: male rats; tmjoa; estrogen; temporomandibular joint ... See more keywords
Trehalose Alleviates the Advancement of Temporomandibular Joint Osteoarthritis via Regulating the AMPK/ULK1 Autophagy Pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Oral diseases"
DOI: 10.1111/odi.70122
Abstract: OBJECTIVE TMJOA is a chronic degenerative joint disorder with multiple etiologies that significantly impair patients' quality of life. Autophagy and apoptosis are critical to the pathogenesis of TMJOA. Trehalose is a novel autophagy activator and… read more here.
Keywords: joint; tmjoa; autophagy; pathway ... See more keywords
Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/2581151
Abstract: The mechanism of temporomandibular joint osteoarthritis (TMJOA), which leads to the final erosion of cartilage and subchondral bone, has been widely demonstrated, but still not clearly elucidated. Many studies have pointed that NLRP3-mediated inflammation played… read more here.
Keywords: tmjoa; pyroptosis; temporomandibular joint; joint osteoarthritis ... See more keywords
Loss of RAP2A Aggravates Cartilage Degradation in TMJOA via YAP Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221132213
Abstract: Abnormal stress loading has been considered a major contributor to the initiation of temporomandibular joint osteoarthritis (TMJOA), but studies to date have not identified a functional molecule that transforms physical stress into biological or biochemical… read more here.
Keywords: loss rap2a; tmjoa; cartilage degradation; yap ... See more keywords
Artificial Cell-Derived Vesicles: Extracellular Vesicle Mimetics for Chondrocyte Restoration in TMJOA Therapy
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s508449
Abstract: Purpose Cartilage repair in temporomandibular joint osteoarthritis (TMJOA) remains a clinical challenge. Despite the strong repair potential of extracellular vesicles (EVs), their clinical use is constrained by yield and purification issues. This study explores artificial… read more here.
Keywords: derived vesicles; repair; artificial cell; tmjoa ... See more keywords
Metabolic profiling of synovial fluid in human temporomandibular joint osteoarthritis
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1335181
Abstract: Introduction Temporomandibular joint (TMJ) osteoarthritis (OA) is a common TMJ degenerative disease with an unclear mechanism. Synovial fluid (SF), an important component of TMJ, contains various proteins and metabolites that may directly contribute to OA.… read more here.
Keywords: metabolic profiling; temporomandibular joint; synovial fluid; tmjoa ... See more keywords
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2024 at "Biomaterials Research"
DOI: 10.34133/bmr.0073
Abstract: The pathogenesis of temporomandibular joint osteoarthritis (TMJOA) is closely associated with mechanical friction, which leads to the up-regulation of inflammatory mediators and the degradation of articular cartilage. Injectable drug-loaded microparticles have attracted widespread interest in… read more here.
Keywords: temporomandibular joint; hyaluronic acid; drug; tmjoa ... See more keywords