Determination of TMPRSS2‐ERG, SPOP, FOXA1, and IDH1 prostate cancer molecular subtypes in Colombian patients and their possible implications for prognosis
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.12000
Abstract: Prostate cancer (PCa) is one of cancer with of the highest incidence and mortality worldwide. Current disease prognostic markers do not differentiate aggressive from indolent PCa with sufficient certainty, and characterization by molecular subtypes has… read more here.
Keywords: molecular subtypes; spop foxa1; foxa1 idh1; tmprss2 erg ... See more keywords
Characterization of stage-specific tumor progression in TMPRSS2-ERG (fusion)-driven and non-fusion-driven prostate cancer in GEM models.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23413
Abstract: In the present study, we performed a comparative stage-specific pathological and molecular marker evaluation of TMPRSS2-ERG fusion and PTEN loss-driven (TMPRSS2-ERG. Ptenflox/flox ) versus non-fusion-driven prostate tumorigenesis (Hi-Myc) in mice. Anterior, ventral, and dorsolateral prostates… read more here.
Keywords: fusion driven; fusion; erg fusion; stage ... See more keywords
Corrigendum re: "TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer" [Eur Urol 2016;70:709-13].
Sign Up to like & getrecommendations! Published in 2017 at "European urology"
DOI: 10.1016/j.eururo.2017.02.027
Abstract: a Translational Genomics and Targeted Therapeutics in Solid Tumours Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; b Medical Oncology Department, Hospital Clı́nic, Barcelona, Spain; c Fundació Clı́nic per a la Recerca… read more here.
Keywords: tmprss2 erg; erg blood; barcelona spain; oncology ... See more keywords
Prostate cancer: Stuck in the middle: interstitial genes in TMPRSS2–ERG fusion
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/nrurol.2017.208
Abstract: more frequently in very-low-risk and low-risk prostate cancer tumours than in tumours in higher risk categories. Furthermore, fusions containing interstitial genes are less likely to be associated with biochemical recurrence. Identifying patients with fusion-positive cancer… read more here.
Keywords: risk; tmprss2 erg; erg fusion; low risk ... See more keywords
Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-0686
Abstract: E26 transformation-specific transcription factor ERG is aberrantly overexpressed in approximately 50% of all human prostate cancer due to TMPRSS2-ERG gene rearrangements. However, mice with prostate-specific transgenic expression of prostate cancer-associated ERG alone fail to develop… read more here.
Keywords: prostate; tmprss2 erg; tumorigenesis; foxo1 ... See more keywords
Nifuroxazide Activates the Parthanatos to Overcome TMPRSS2:ERG Fusion-Positive Prostate Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-22-0159
Abstract: Abstract Fusion of the E-26 transformation-specific (ETS)-related gene (ERG) with transmembrane serine protease 2 (TMPRSS2) is a crucial step in the occurrence and progression of approximately 50% of prostate cancers. Despite significant progress in drug… read more here.
Keywords: fusion; prostate cancer; cancer; tmprss2 erg ... See more keywords
Editor's Note: Inactivation of AR/TMPRSS2-ERG/Wnt Signaling Networks Attenuates the Aggressive Behavior of Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Prevention Research"
DOI: 10.1158/1940-6207.capr-18-0315
Abstract: The editors are publishing this note to alert readers to concerns about this article (1). An institutional investigation determined that the same image was used to represent two different experimental conditions (LNCaP BR-DIM and VCaP… read more here.
Keywords: inactivation tmprss2; tmprss2 erg; erg wnt; editor note ... See more keywords
SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Cell International"
DOI: 10.1186/s12935-020-01333-5
Abstract: Background Prostate cancer (PCa) is the second cause of cancer related death in North American men. Androgens play an important role in its progression by regulating the expression of several genes including fusion ones that results from… read more here.
Keywords: tmprss2 erg; sfrp1 protein; expression; cancer ... See more keywords
TMPRSS2: ERG expression in prostate cancer—Imaging and clinicopathological correlations.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.284
Abstract: 284Background: The TMPRSS2:ERG gene fusion (T:E) is found in up to 70% of prostate cancers (PCa) and results in androgen dependent overexpression of ERG, promoting tumor growth. The early identific... read more here.
Keywords: prostate; tmprss2 erg; expression prostate; prostate cancer ... See more keywords
miR-449a Repression Leads to Enhanced NOTCH Signaling in TMPRSS2:ERG Fusion Positive Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13050964
Abstract: Simple Summary The reason for the frequent presence of the TMPRSS2:ERG (T2E) gene fusion in prostate cancer (PCa) is not fully understood. We were interested in investigating epigenomic alterations associated with the T2E gene fusion… read more here.
Keywords: tmprss2 erg; prostate cancer; pca; expression ... See more keywords
Identification of F-Box/SPRY Domain-Containing Protein 1 (FBXO45) as a Prognostic Biomarker for TMPRSS2–ERG-Positive Primary Prostate Cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15061890
Abstract: Simple Summary FBXO45 plays a role in the regulation of apoptosis through the ubiquitylation and degradation of specific target proteins. While FBXO45 has been suggested to have prognostic potential in various cancers, its specific role… read more here.
Keywords: pca; tmprss2 erg; expression; erg positive ... See more keywords