Host Serine Proteases TMPRSS2 and TMPRSS11D Mediate Proteolytic Activation and Trypsin-Independent Infection in Group A Rotaviruses
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DOI: 10.1128/jvi.00398-21
Abstract: Proteolytic cleavage of the viral VP4 protein is essential for virion maturation and infectivity in group A rotaviruses (RVAs). In cell culture, RVAs are propagated in culture medium supplemented with the exogenous protease trypsin, which… read more here.
Keywords: activation; group rotaviruses; infection; tmprss2 tmprss11d ... See more keywords