TRPC5 mediates TMZ resistance in TMZ-resistant glioblastoma cells via NFATc3-P-gp pathway
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101214
Abstract: P-glycoprotein (P-gp) acts as a pump to transport cytotoxic drugs out of cells and is upregulated in cancer cells. Suppressing the expression of P-gp is an effective strategy to overcome multidrug resistance in cancer chemotherapy.… read more here.
Keywords: glioblastoma; tmz resistant; trpc5; tmz resistance ... See more keywords
Nano-Codelivery of Temozolomide and siPD-L1 to Reprogram the Drug-Resistant and Immunosuppressive Microenvironment in Orthotopic Glioblastoma.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c09794
Abstract: Glioblastoma (GBM) is an invasive cancer with high mortality in central nervous system. Resistance to temozolomide (TMZ) and immunosuppressive microenvironment lead to low outcome of the standardized treatment for GBM. In this study, a 2-deoxy-d-glucose… read more here.
Keywords: orthotopic; tmz resistant; tmz sipd; resistant gbm ... See more keywords
DDDR-16. SORTING TO ENRICH FOR CHEMOTHERAPEUTIC-RESISTANT GLIOMA CELLS BASED ON UNIQUE MEMBRANE PROPERTIES
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0501
Abstract: Glioblastoma, astrocytoma, and oligodendroglioma comprise a class of aggressive and deadly brain tumors called diffuse gliomas. Around 20,000 glioma cases are diagnosed yearly in the US alone. The current standard chemotherapy treatment, temozolomide (TMZ), is… read more here.
Keywords: tmz resistant; glioma cells; resistant cells; membrane ... See more keywords
Notch1 and Major Vault Proteins Modulate Temozolomide Resistance in Glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70474
Abstract: The development of resistance to chemotherapy in the case of aggressive glioblastoma multiforme (GBM) presents a significant treatment challenge. Dysregulation of the Notch signalling pathway promotes tumour proliferation in GBM cells. This study was that… read more here.
Keywords: resistance; gbm cells; major vault; gbm ... See more keywords
FOXM1‐mediated NUF2 expression confers temozolomide resistance to human glioma cells by regulating autophagy via the PI3K/AKT/mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology"
DOI: 10.1111/neup.12824
Abstract: Glioma is the most common malignant tumor in the central nervous system and has a high mortality rate. Temozolomide (TMZ) is a widely used chemotherapeutic drug for glioma. NDC80 kinetochore complex (NUF2) is suggested to… read more here.
Keywords: cells regulating; tmz resistant; glioma cells; human glioma ... See more keywords
Abstract 5009: Inhibition of TGFBR2 signaling re-sensitizes TMZ-resistant glioblastoma cells to therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5009
Abstract: Glioblastoma (GBM), the most aggressive and lethal form of brain tumors, recurs in 90% of cases and the standard protocol of care—temozolomide (TMZ)—is an ineffective method to combat chemo-resistant GBM. It is therefore imperative that… read more here.
Keywords: inhibition tgfbr2; glioblastoma; gbm; tmz resistant ... See more keywords
The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of molecular sciences"
DOI: 10.3390/ijms221910247
Abstract: BACKGROUND Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. It is highly resistant to chemotherapy, and tumor recurrence is common. Neuronal precursor cell-expressed developmentally downregulated 4-1 (NEDD4-1) is an E3 ligase… read more here.
Keywords: glioblastoma; tmz resistant; gbm cells; nedd4 ... See more keywords
Multiple Pathway-Dephosphorylated ASK-1 Confers Temozolomide-Resistance to Human Glioma Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Turkish neurosurgery"
DOI: 10.5137/1019-5149.jtn.41212-22.1
Abstract: AIM Temozolomide (TMZ) resistance contributes to the unfavorable prognosis of glioma, however, the mechanism of resistance is unknown. ASK-1 has various functions in many tumors, but its function in glioma is poorly understood. This study… read more here.
Keywords: u87 u251; tmz resistant; glioma cells; ask ... See more keywords