The PI3K/mTOR dual inhibitor NVP‐BEZ235 stimulates mutant p53 degradation to exert anti‐tumor effects on triple‐negative breast cancer cells
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DOI: 10.1002/2211-5463.12806
Abstract: Nearly half of human cancers harbor p53 mutations, and mutant p53 (mutp53) promotes carcinogenesis, metastasis, tumor recurrence and chemoresistance. mutp53 is observed in 30% of breast carcinomas, including triple‐negative breast cancer (TNBC), and thus mutp53… read more here.
Keywords: degradation; bez235; tnbc; mutant p53 ... See more keywords
NADPH Selective Depletion Nanomedicine‐Mediated Radio‐Immunometabolism Regulation for Strengthening Anti‐PDL1 Therapy against TNBC
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DOI: 10.1002/advs.202203788
Abstract: Anti‐PD(L)1 immunotherapy recently arises as an effective treatment against triple‐negative breast cancer (TNBC) but is only applicable to a small portion of TNBC patients due to the low PD‐L1 expression and the immunosuppressive tumor microenvironment… read more here.
Keywords: radio immunometabolism; nanomedicine mediated; therapy; tnbc ... See more keywords
Mace‐Like Plasmonic Au‐Pd Heterostructures Boost Near‐Infrared Photoimmunotherapy
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DOI: 10.1002/advs.202204842
Abstract: Photoimmunotherapy, with spatiotemporal precision and noninvasive property, has provided a novel targeted therapeutic strategy for highly malignant triple‐negative breast cancer (TNBC). However, their therapeutic effect is severely restricted by the insufficient generation of tumor antigens… read more here.
Keywords: near infrared; like plasmonic; boost near; plasmonic heterostructures ... See more keywords
Hypoxia‐Induced FUS–circTBC1D14 Stress Granules Promote Autophagy in TNBC
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DOI: 10.1002/advs.202204988
Abstract: Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that is suggested to be associated with hypoxia. This study is the first to identify a novel circular RNA (circRNA), circTBC1D14, whose expression… read more here.
Keywords: stress granules; fus circtbc1d14; hypoxia; tnbc ... See more keywords
Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions
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DOI: 10.1002/advs.202205873
Abstract: Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo‐resistance, metastasis, and TNBC‐related death.… read more here.
Keywords: resistance metastasis; phosphorylation usp29; twist1; cdk1 ... See more keywords
SOSTDC1 Nuclear Translocation Facilitates BTIC Maintenance and CHD1‐Mediated HR Repair to Promote Tumor Progression and Olaparib Resistance in TNBC
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DOI: 10.1002/advs.202306860
Abstract: Breast tumor‐initiating cells (BTICs) of triple‐negative breast cancer (TNBC) tissues actively repair DNA and are resistant to treatments including chemotherapy, radiotherapy, and targeted therapy. Herein, it is found that a previously reported secreted protein, sclerostin… read more here.
Keywords: maintenance; tnbc; tumor; btic maintenance ... See more keywords
CircCFL1 Promotes TNBC Stemness and Immunoescape via Deacetylation‐Mediated c‐Myc Deubiquitylation to Facilitate Mutant TP53 Transcription
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DOI: 10.1002/advs.202404628
Abstract: Triple‐negative breast cancer (TNBC) is the most malignant subtype of breast cancer. TP53, which has a mutation rate of ≈70%–80% in TNBC patients, plays oncogenic roles when mutated. However, whether circRNAs can exert their effects… read more here.
Keywords: via deacetylation; deacetylation mediated; mutant tp53; tnbc ... See more keywords
Triple-Negative Breast Cancer Cells Resist Natural Killer Cell-Mediated Killing Through Interleukin-11 Trans-Signaling.
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DOI: 10.1002/advs.202515772
Abstract: Natural killer (NK) cell‐based therapies show great promise for treating triple‐negative breast cancer (TNBC). However, in the tumor microenvironment, some TNBC cells develop resistance to NK cell‐mediated killing and contribute to NK cell exhaustion. In… read more here.
Keywords: trans signaling; cell; mediated killing; cell mediated ... See more keywords
Regulation of DNA‐PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid‐derived suppressor cells
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DOI: 10.1002/cam4.5387
Abstract: DNA‐dependent protein kinase (DNA‐PK) is engaged in DNA damage repair and is significantly expressed in triple negative breast cancer (TNBC). Inhibiting DNA‐PK to reduce DNA damage repair provides a possibility of tumor treatment. NU7441, a… read more here.
Keywords: function; dna; myeloid derived; suppressor cells ... See more keywords
Proteolysis Targeting Chimera (PROTAC) as a promising novel therapeutic modality for the treatment of triple-negative breast cancer (TNBC).
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22055
Abstract: Breast cancer (BC) is considered one of the most prevalent malignancies impacting women worldwide, constituting 15% of all new cancer cases. It is classified according to its molecular targets into three subtypes; HR+/ERBB2-, ERBB2+/HR+, or… read more here.
Keywords: breast cancer; therapeutic modality; cancer; tnbc ... See more keywords
Integration of whole‐genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple‐negative breast cancer
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DOI: 10.1002/ijc.32329
Abstract: Lung metastasis is one of the leading causes of death for triple‐negative breast cancer (TNBC). We sought to characterize the genetic alterations underlying TNBC lung metastases by integrating whole‐genome sequencing and functional screening. Furthermore, we… read more here.
Keywords: whole genome; metastasis; tnbc; signature ... See more keywords