The PI3K/mTOR dual inhibitor NVP‐BEZ235 stimulates mutant p53 degradation to exert anti‐tumor effects on triple‐negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12806
Abstract: Nearly half of human cancers harbor p53 mutations, and mutant p53 (mutp53) promotes carcinogenesis, metastasis, tumor recurrence and chemoresistance. mutp53 is observed in 30% of breast carcinomas, including triple‐negative breast cancer (TNBC), and thus mutp53… read more here.
Keywords: degradation; bez235; tnbc; mutant p53 ... See more keywords
NADPH Selective Depletion Nanomedicine‐Mediated Radio‐Immunometabolism Regulation for Strengthening Anti‐PDL1 Therapy against TNBC
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203788
Abstract: Anti‐PD(L)1 immunotherapy recently arises as an effective treatment against triple‐negative breast cancer (TNBC) but is only applicable to a small portion of TNBC patients due to the low PD‐L1 expression and the immunosuppressive tumor microenvironment… read more here.
Keywords: radio immunometabolism; nanomedicine mediated; therapy; tnbc ... See more keywords
Mace‐Like Plasmonic Au‐Pd Heterostructures Boost Near‐Infrared Photoimmunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204842
Abstract: Photoimmunotherapy, with spatiotemporal precision and noninvasive property, has provided a novel targeted therapeutic strategy for highly malignant triple‐negative breast cancer (TNBC). However, their therapeutic effect is severely restricted by the insufficient generation of tumor antigens… read more here.
Keywords: near infrared; like plasmonic; boost near; plasmonic heterostructures ... See more keywords
Hypoxia‐Induced FUS–circTBC1D14 Stress Granules Promote Autophagy in TNBC
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204988
Abstract: Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that is suggested to be associated with hypoxia. This study is the first to identify a novel circular RNA (circRNA), circTBC1D14, whose expression… read more here.
Keywords: stress granules; fus circtbc1d14; hypoxia; tnbc ... See more keywords
Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205873
Abstract: Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo‐resistance, metastasis, and TNBC‐related death.… read more here.
Keywords: resistance metastasis; phosphorylation usp29; twist1; cdk1 ... See more keywords
Regulation of DNA‐PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid‐derived suppressor cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5387
Abstract: DNA‐dependent protein kinase (DNA‐PK) is engaged in DNA damage repair and is significantly expressed in triple negative breast cancer (TNBC). Inhibiting DNA‐PK to reduce DNA damage repair provides a possibility of tumor treatment. NU7441, a… read more here.
Keywords: function; dna; myeloid derived; suppressor cells ... See more keywords
Proteolysis Targeting Chimera (PROTAC) as a promising novel therapeutic modality for the treatment of triple-negative breast cancer (TNBC).
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22055
Abstract: Breast cancer (BC) is considered one of the most prevalent malignancies impacting women worldwide, constituting 15% of all new cancer cases. It is classified according to its molecular targets into three subtypes; HR+/ERBB2-, ERBB2+/HR+, or… read more here.
Keywords: breast cancer; therapeutic modality; cancer; tnbc ... See more keywords
Integration of whole‐genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple‐negative breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32329
Abstract: Lung metastasis is one of the leading causes of death for triple‐negative breast cancer (TNBC). We sought to characterize the genetic alterations underlying TNBC lung metastases by integrating whole‐genome sequencing and functional screening. Furthermore, we… read more here.
Keywords: whole genome; metastasis; tnbc; signature ... See more keywords
Differential optineurin expression controls TGFβ signaling and is a key determinant for metastasis of triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34483
Abstract: Triple‐negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat due to its aggressive characteristics and low response to the existing clinical therapies. Distant metastasis is the main cause of death of… read more here.
Keywords: metastasis; expression; breast cancer; tnbc ... See more keywords
Role of Wnt Co‐Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25956
Abstract: The low‐density lipoprotein receptor‐related protein 6 (LRP6) is an essential Wnt co‐receptor of the Wnt/β‐catenin signaling pathway. Although studies have shown an increased expression of LRP6 in several types of cancer, its function in tumor… read more here.
Keywords: cell migration; tnbc; cancer; cell ... See more keywords
Long non‐coding RNA (LncRNA) RMST in triple‐negative breast cancer (TNBC): Expression analysis and biological roles research
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26311
Abstract: Microarray showed that lncRNA RMST was differentially expressed in cervical cancer. Further experiments were conducted to detect the expression and biological function of RMST in triple‐negative breast cancer (TNBC). Microarray was used to screen the… read more here.
Keywords: rmst; lncrna rmst; tnbc; expression ... See more keywords