Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple‐Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202205462
Abstract: Lung metastasis is challenging in patients with triple‐negative breast cancer (TNBC). Surgery is always not available due to the dissemination of metastatic foci and most drugs are powerless because of poor retention at metastatic sites.… read more here.
Keywords: lung; tnbc cells; lung metastasis; walking dead ... See more keywords
Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Drug delivery and translational research"
DOI: 10.1007/s13346-022-01137-2
Abstract: To date, promising therapy for triple negative breast cancer (TNBC) remains a serious concern clinically because of poor prognosis, resistance, and recurrence. Herein, anti-cancer potential of synthetic cannabidiol (CBD; Purisys, GA; GMP grade) was explored… read more here.
Keywords: integrin; tnbc; tnbc cells; treatment ... See more keywords
SOX10 induced Nestin expression regulates cancer stem cell properties of TNBC cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.014
Abstract: The mechanisms modulating the cancer stem cell (CSC) properties of triple negative breast cancer (TNBC) cells were not fully understood. In this study, we performed data mining in Breast Cancer Gene-Expression Miner v4.0 and found… read more here.
Keywords: cancer stem; tnbc cells; breast cancer; stem cell ... See more keywords
USP18 reduces paclitaxol sensitivity of triple-negative breast cancer via autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.02.048
Abstract: Paclitaxol is a first-line treatment for triple-negative breast cancer (TNBC). The molecular mechanisms underlying paclitaxol resistance in TNBC remain largely unclear. In this study, differential expressed genes (DEGs) between TNBC cells and paclitaxol-resistant (taxol-R) TNBC… read more here.
Keywords: triple negative; tnbc; negative breast; breast cancer ... See more keywords
Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01682
Abstract: AXL kinase is heavily involved in tumorigenesis, metastasis, and drug resistance of many cancers, and several AXL inhibitors are in clinical investigations. Recent studies demonstrated that the N-terminal distal region of AXL plays more important… read more here.
Keywords: discovery axl; axl degraders; improved potencies; degraders improved ... See more keywords
G2/M-Phase-Inhibitory Mitochondrial-Depolarizing Re(I)/Ru(II)/Ir(III)-2,2′-Bipyrimidine-Based Heterobimetallic Luminescent Complexes: An Assessment of In Vitro Antiproliferative Activity and Bioimaging for Targeted Therapy toward Human TNBC Cells
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c08285
Abstract: Triple-negative breast cancer (TNBC) is an extremely vicious subtype of human breast cancer having the worst prognosis along with strong invasive and metastatic competency. Hence, it can easily invade into blood vessels, and presently, no… read more here.
Keywords: iii bipyrimidine; activity; tnbc; tnbc cells ... See more keywords
Extracellular ATP promotes angiogenesis and adhesion of TNBC cells to endothelial cells via upregulation of CTGF
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15375
Abstract: Our previous works have indicated that extracellular ATP is an important prometastasis factor. However, the molecular mechanism involved needs to be further studied. We demonstrated that extracellular ATP treatment could upregulate the expression of connective… read more here.
Keywords: adhesion; ctgf; tnbc cells; atp ... See more keywords
lncRNA GHET1 Promotes the Progression of Triple-Negative Breast Cancer via Regulation of miR-377-3p/GRSF1 Signaling Axis
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/8366569
Abstract: Objective This study is aimed at investigating the role of lncRNA GHET1 in the progression of triple-negative breast cancer (TNBC). Methods Tumor tissues and paracancerous tissues (normal) of TNBC patients were collected. Human normal breast… read more here.
Keywords: tnbc cells; 377 grsf1; mir 377; lncrna ghet1 ... See more keywords
The immunosuppressive microenvironment in BRCA1-IRIS-overexpressing TNBC tumors is induced by bidirectional interaction with tumor-associated macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-2374
Abstract: Tumor-associated macrophages (TAMs) promote triple-negative breast cancer (TNBC) progression. Here, we report BRCA1-IRIS overexpressing (IRISOE) TNBC cells secrete high levels of GM-CSF in a HIF-1a- and a NF-kB-dependent manner to recruit macrophages to IRISOE cells… read more here.
Keywords: tnbc cells; tnbc tumors; tnbc; interaction ... See more keywords
Abstract 3552: Selective inhibition of copper metabolism as a novel approach to treat triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3552
Abstract: Rationale: Treatment of patients with triple-negative breast cancer (TNBC) remains challenging due to unpredictable disease progression and acquired resistance to chemotherapy. Finding novel targets in TNBC is important for the development of anticancer therapy. Cancer… read more here.
Keywords: dcac50; inhibition; copper; tnbc cells ... See more keywords
Abstract 5849: Association between annexin-A6 expression and metabolic vulnerabilities of TNBC cells and their response to EGFR-tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-5849
Abstract: PURPOSE: Triple-negative breast cancer (TNBC), and the basal-like TNBC subtype, accounts for ~20% of all breast cancer (BC) cases, and is particularly prevalent in younger patients of African-American and Hispanic descent. The importance of annexin… read more here.
Keywords: kinase inhibitors; anxa6; metabolic vulnerabilities; tnbc cells ... See more keywords