Comparison of the tumor immune microenvironment phenotypes in different breast cancers after neoadjuvant therapy
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DOI: 10.1002/cam4.5207
Abstract: Neoadjuvant therapy (NAT) treats early‐stage breast cancers, especially triple‐negative breast cancers (TNBCs). NAT improves pathological complete response (pCR) rates for different breast cancer patients. Recently, immune checkpoint inhibitors that target programmed death 1 (PD‐1) or… read more here.
Keywords: breast; tnbc patients; breast cancers; tumor ... See more keywords
Development of an immune-related prognostic biomarker for triple-negative breast cancer
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DOI: 10.1080/07853890.2022.2067894
Abstract: Abstract Purpose: Oncology studies employing digital dissection methodologies have provided some insight on the biological features of tumor microenvironment of Triple-negative breast cancer (TNBC), but molecular diagnostics rarely have therapeutic impact. We aimed to identify… read more here.
Keywords: biomarker; breast cancer; tnbc patients; tnbc ... See more keywords
Diabetes regulated anti-inflammatory lncRNA is overexpressed in triple-negative breast cancer and predicts chemoresistance and tumor recurrence
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DOI: 10.1080/21655979.2022.2068821
Abstract: ABSTRACT Diabetes regulated anti-inflammatory lncRNA (DRAIR) has been characterized as a critical player in type 2 diabetes mellitus. However, its role in other human diseases is unclear. Our preliminary sequencing analysis revealed an altered DRAIR… read more here.
Keywords: drair; tumor; tumor recurrence; tnbc patients ... See more keywords
PO-347 sONE, a novel tumour suppressor lncRNA, with diminished expression level in young triple negative breast cancer (TNBC) patients with lymphnode metastasis and large tumour size
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DOI: 10.1136/esmoopen-2018-eacr25.859
Abstract: Introduction A recent surveillance of the human transcriptome has highlighted a pivotal class of RNA known as long non-coding RNA (lncRNAs). Myriad studies have reported the vital role of lncRNAs in oncology. However, the field… read more here.
Keywords: tnbc patients; level; sone; expression ... See more keywords
743 High levels of stromal tumor infiltrating lymphocytes, CD3, CD8 cells & Immunoscore® are associated with pathological CR and time to progression in TNBC patients undergoing neo-adjuvant chemotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0743
Abstract: Background The presence of high levels of stromal tumor infiltrating lymphocytes (TILs) has been associated with better prognosis in early triple-negative breast cancer (TNBC). The Immunoscore® (IS) is a prognostic tool, which categorizes the densities… read more here.
Keywords: patients patients; tnbc patients; cd8; high levels ... See more keywords
The expression of androgen receptor in triple-negative breast cancer and the effect of a traditional Chinese medicine formula on disease-free survival
Sign Up to like & getrecommendations! Published in 2022 at "Gland Surgery"
DOI: 10.21037/gs-22-508
Abstract: Background Androgen receptor (AR) is becoming an important factor in the pathogenesis of breast cancer. Traditional Chinese medicine (TCM) is widely used in treating breast cancer patients. Triple-negative breast cancer (TNBC) is a subtype of… read more here.
Keywords: breast cancer; medicine; tnbc patients; expression ... See more keywords
Prognosis Prediction Through an Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Data in Triple-Negative Breast Cancer
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DOI: 10.3389/fgene.2022.928175
Abstract: Background: Genomic and antigenic heterogeneity pose challenges in the precise assessment of outcomes of triple-negative breast cancer (TNBC) patients. Thus, this study was designed to investigate the cardinal genes related to cell differentiation and tumor… read more here.
Keywords: cell; prognosis prediction; breast cancer; analysis ... See more keywords
A Systematic Review to Clarify the Prognostic Values of CD44 and CD44+CD24- Phenotype in Triple-Negative Breast Cancer Patients: Lessons Learned and The Road Ahead
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DOI: 10.3389/fonc.2021.689839
Abstract: As a unique population of tumor bulk, cancer stem cells have been implicated in tumor relapse and chemoresistance in triple-negative breast cancer (TNBC). Therefore, understanding the phenotype of cancer stem cells can pave the way… read more here.
Keywords: phenotype; tnbc patients; cd44 cd44; cd44 cd24 ... See more keywords
A Novel Risk-Scoring System to Identify the Potential Population Benefiting From Adjuvant Chemotherapy for Node-Negative TNBC Patients With Tumor Size Less Than 1 cm
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DOI: 10.3389/fonc.2022.788883
Abstract: Background and Objectives Whether chemotherapy is needed in node-negative triple-negative breast cancer (TNBC) patients with tumor size less than 1 cm is still controversial. In our research, we constructed a novel risk-scoring system to identify… read more here.
Keywords: risk scoring; tumor size; risk; tnbc patients ... See more keywords
The Prognostic and Therapeutic Implications of the Chemoresistance Gene BIRC5 in Triple-Negative Breast Cancer
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DOI: 10.3390/cancers14215180
Abstract: Simple Summary TNBC is the most aggressive type of breast cancer affecting women worldwide, and chemoresistance poses a significant clinical challenge associated with a poor prognosis. The molecular mechanisms causing this treatment resistance in TNBC… read more here.
Keywords: gene; tnbc patients; tnbc; birc5 ... See more keywords
Immune-Related Gene Signatures to Predict the Effectiveness of Chemoimmunotherapy in Triple-Negative Breast Cancer Using Exploratory Subgroup Discovery
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DOI: 10.3390/cancers14235806
Abstract: Simple Summary Chemoimmunotherapy combinations have transformed the treatment landscape for patients with triple-negative breast cancer (TNBC). However, the discovery of immune-related biomarkers is needed to optimally identify patients requiring the addition of immune-checkpoint inhibitors (ICIs)… read more here.
Keywords: immune related; breast cancer; tnbc patients; tnbc ... See more keywords