Possible Curative Effects of Boric Acid and Bacillus clausii Treatments on TNBS-Induced Ulcerative Colitis in Rats.
Sign Up to like & getrecommendations! Published in 2022 at "Biological trace element research"
DOI: 10.1007/s12011-022-03215-5
Abstract: Crohn's disease (CD) and ulcerative colitis (UC) are two chronic relapsing inflammatory bowel diseases (IBD). Although there are several treatment options available to improve the symptoms of IBD patients, there is no effective treatment that… read more here.
Keywords: group; acid bacillus; boric acid; tnbs induced ... See more keywords
Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12562-6
Abstract: Baicalein (5,6,7-trihydroxyflavone), a predominant bioactive component isolated from the root of Scutellaria baicalensis Georgi, has established potent anti-inflammatory activity via multi-targeted mechanisms. However, little is known about the effect of baicalein on 2,4,6-trinitrobenzene sulfonic acid… read more here.
Keywords: tnbs induced; tlr4 myd88; baicalein; myd88 signaling ... See more keywords
Effect of Loureirin B on Crohn’s disease rat model induced by TNBS via IL-6/STAT3/NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Medicine"
DOI: 10.1186/s13020-019-0282-5
Abstract: BackgroundCrohn’s disease (CD) is a chronic relapsing form of inflammatory bowel disease, seriously threatening human beings health. However, the pathogenesis of CD is still unclear and there is no specific effective drug for treatment of… read more here.
Keywords: tnbs induced; induced tnbs; disease; effect ... See more keywords
Prenylated flavonoid morusin protects against TNBS-induced colitis in rats
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DOI: 10.1371/journal.pone.0182464
Abstract: Morusin is a prenylated flavonoid isolated from the root bark of Morus alba. Many studies have shown the ability of flavonoids to act as anti-inflammatory agents. The aim of this study was to evaluate the… read more here.
Keywords: prenylated flavonoid; protects tnbs; tnbs induced; flavonoid morusin ... See more keywords
Niacin ameliorates ulcerative colitis via prostaglandin D2‐mediated D prostanoid receptor 1 activation
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DOI: 10.15252/emmm.201606987
Abstract: Niacin, as an antidyslipidemic drug, elicits a strong flushing response by release of prostaglandin (PG) D2. However, whether niacin is beneficial for inflammatory bowel disease (IBD) remains unclear. Here, we observed niacin administration‐enhanced PGD2 production… read more here.
Keywords: prostanoid receptor; prostaglandin; tnbs induced; colitis ... See more keywords
2,4,6-trinitrobenzenesulfonic acid-induced colitis in Rattus norgevicus: a categorization proposal
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Animals"
DOI: 10.1538/expanim.20-0113
Abstract: Reproducibility in animal research is crucial for its reliance and translational relevance. The 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced model of inflammatory bowel disease (IBD) is widely used but inconsistently and incompletely characterized throughout the literature. This… read more here.
Keywords: tnbs induced; colitis; trinitrobenzenesulfonic acid; rattus ... See more keywords
High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice
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DOI: 10.18632/oncotarget.13783
Abstract: This study focuses on characterizing the effect of a high salt diet (HSD) on intestinal immunity and the risk of inflammatory bowel diseases (IBD). We found that mice on a HSD had an increased frequency… read more here.
Keywords: tnbs induced; response; salt diet; colitis ... See more keywords
Investigation of the relationship between the Th17/IL-23 pathway and innate-adaptive immune system in TNBS-induced colitis in rats
Sign Up to like & getrecommendations! Published in 2017 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2017.9108
Abstract: Objective(s): This study was aimed at investigating immune activations of the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model in colonic mucosa by immunohistochemical and Western blot methods. Materials and Methods: For this purpose, 16 female Wistar… read more here.
Keywords: th17 pathway; tnbs induced; colitis group; anti ... See more keywords
Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.883918
Abstract: Aim of the study: To evaluate the protective effect and mechanism of shenling baizhu powder (SBP) on TNBS-induced colitis. Methods: Rats were given TNBS to establish the model of colitis and subsequently treated with different… read more here.
Keywords: tnbs induced; induced colitis; shenling baizhu; tlr5 myd88 ... See more keywords
Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis
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DOI: 10.3390/ijms23169127
Abstract: Inflammatory bowel disease (IBD) is characterized by a chronic and relapsing inflammatory response in the gastrointestinal tract, resulting in severe symptoms such as abdominal pain, vomiting, diarrhea, bloody stools, and weight loss. Currently, there is… read more here.
Keywords: tnbs induced; effect; anti inflammatory; topiramate ... See more keywords
In Silico Study and Effects of BDMC33 on TNBS-Induced BMP Gene Expressions in Zebrafish Gut Inflammation-Associated Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27238304
Abstract: The bone morphogenic protein (BMP) family is a member of the TGF-beta superfamily and plays a crucial role during the onset of gut inflammation and arthritis diseases. Recent studies have reported a connection with the… read more here.
Keywords: inflammation; tnbs induced; associated arthritis; arthritis ... See more keywords