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   Articles with "tnbs induced" as a keyword



Possible Curative Effects of Boric Acid and Bacillus clausii Treatments on TNBS-Induced Ulcerative Colitis in Rats.

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recommendations! Published in 2022 at "Biological trace element research"

DOI: 10.1007/s12011-022-03215-5

Abstract: Crohn's disease (CD) and ulcerative colitis (UC) are two chronic relapsing inflammatory bowel diseases (IBD). Although there are several treatment options available to improve the symptoms of IBD patients, there is no effective treatment that… read more here.

Keywords: group; acid bacillus; boric acid; tnbs induced ... See more keywords

Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-12562-6

Abstract: Baicalein (5,6,7-trihydroxyflavone), a predominant bioactive component isolated from the root of Scutellaria baicalensis Georgi, has established potent anti-inflammatory activity via multi-targeted mechanisms. However, little is known about the effect of baicalein on 2,4,6-trinitrobenzene sulfonic acid… read more here.

Keywords: tnbs induced; tlr4 myd88; baicalein; myd88 signaling ... See more keywords

Desloratadine via its anti-inflammatory and antioxidative properties ameliorates TNBS-induced experimental colitis in rats

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recommendations! Published in 2024 at "Immunopharmacology and Immunotoxicology"

DOI: 10.1080/08923973.2024.2360043

Abstract: Abstract Background Intestinal mucosal immune cells, notably mast cells, are pivotal in ulcerative colitis (UC) pathophysiology. Its activation elevates tissue concentrations of histamine. Inhibiting colonic histamine release could be an effective therapeutic strategy for treating… read more here.

Keywords: colitis rats; tnbs induced; antioxidative properties; anti inflammatory ... See more keywords
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Effect of Loureirin B on Crohn’s disease rat model induced by TNBS via IL-6/STAT3/NF-κB signaling pathway

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recommendations! Published in 2020 at "Chinese Medicine"

DOI: 10.1186/s13020-019-0282-5

Abstract: BackgroundCrohn’s disease (CD) is a chronic relapsing form of inflammatory bowel disease, seriously threatening human beings health. However, the pathogenesis of CD is still unclear and there is no specific effective drug for treatment of… read more here.

Keywords: tnbs induced; induced tnbs; disease; effect ... See more keywords

Prenylated flavonoid morusin protects against TNBS-induced colitis in rats

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0182464

Abstract: Morusin is a prenylated flavonoid isolated from the root bark of Morus alba. Many studies have shown the ability of flavonoids to act as anti-inflammatory agents. The aim of this study was to evaluate the… read more here.

Keywords: prenylated flavonoid; protects tnbs; tnbs induced; flavonoid morusin ... See more keywords

Protective effect of sucrose esters from cape gooseberry (Physalis peruviana L.) in TNBS-induced colitis

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recommendations! Published in 2024 at "PLOS ONE"

DOI: 10.1371/journal.pone.0299687

Abstract: Phytotherapy is an attractive strategy to treat inflammatory bowel disease (IBD) that could be especially useful in developing countries. We previously demonstrated the intestinal anti-inflammatory effect of the total ethereal extract from the Physalis peruviana… read more here.

Keywords: effect; tnbs induced; sucrose esters; colitis ... See more keywords

Niacin ameliorates ulcerative colitis via prostaglandin D2‐mediated D prostanoid receptor 1 activation

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recommendations! Published in 2017 at "EMBO Molecular Medicine"

DOI: 10.15252/emmm.201606987

Abstract: Niacin, as an antidyslipidemic drug, elicits a strong flushing response by release of prostaglandin (PG) D2. However, whether niacin is beneficial for inflammatory bowel disease (IBD) remains unclear. Here, we observed niacin administration‐enhanced PGD2 production… read more here.

Keywords: prostanoid receptor; prostaglandin; tnbs induced; colitis ... See more keywords
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2,4,6-trinitrobenzenesulfonic acid-induced colitis in Rattus norgevicus: a categorization proposal

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recommendations! Published in 2021 at "Experimental Animals"

DOI: 10.1538/expanim.20-0113

Abstract: Reproducibility in animal research is crucial for its reliance and translational relevance. The 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced model of inflammatory bowel disease (IBD) is widely used but inconsistently and incompletely characterized throughout the literature. This… read more here.

Keywords: tnbs induced; colitis; trinitrobenzenesulfonic acid; rattus ... See more keywords

High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.13783

Abstract: This study focuses on characterizing the effect of a high salt diet (HSD) on intestinal immunity and the risk of inflammatory bowel diseases (IBD). We found that mice on a HSD had an increased frequency… read more here.

Keywords: tnbs induced; response; salt diet; colitis ... See more keywords
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Investigation of the relationship between the Th17/IL-23 pathway and innate-adaptive immune system in TNBS-induced colitis in rats

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recommendations! Published in 2017 at "Iranian Journal of Basic Medical Sciences"

DOI: 10.22038/ijbms.2017.9108

Abstract: Objective(s): This study was aimed at investigating immune activations of the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model in colonic mucosa by immunohistochemical and Western blot methods. Materials and Methods: For this purpose, 16 female Wistar… read more here.

Keywords: th17 pathway; tnbs induced; colitis group; anti ... See more keywords

Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.883918

Abstract: Aim of the study: To evaluate the protective effect and mechanism of shenling baizhu powder (SBP) on TNBS-induced colitis. Methods: Rats were given TNBS to establish the model of colitis and subsequently treated with different… read more here.

Keywords: tnbs induced; induced colitis; shenling baizhu; tlr5 myd88 ... See more keywords