Tenascin-C preserves microglia surveillance and restricts leukocyte and, more specifically, T cell infiltration of the ischemic brain
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DOI: 10.1016/j.bbi.2020.10.016
Abstract: As an endogenous activator of toll-like receptor-4 (Tlr4), the extracellular matrix glycoprotein tenascin-C (TnC) regulates chemotaxis, phagocytosis and proinflammatory cytokine production in microglia. The role of TnC for ischemic brain injury, post-ischemic immune responses and… read more here.
Keywords: microglia surveillance; ischemic brain; brain; tnc deficiency ... See more keywords