The structure of myeloid cell‐specific TNF inhibitors affects their biological properties
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13913
Abstract: Spatial organization and conformational changes of antibodies may significantly affect their biological functions. We assessed the effect of mutual organization of the two VHH domains within bispecific antibodies recognizing human TNF and the surface molecules… read more here.
Keywords: tnf; specific tnf; structure myeloid; myeloid cell ... See more keywords
A cross‐linked anti‐TNF‐α aptamer for neutralization of TNF‐α‐induced cutaneous Shwartzman phenomenon: A simple and novel approach for improving aptamers' affinity and efficiency
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Progress"
DOI: 10.1002/btpr.3191
Abstract: To increase the efficiency of aptamers to their targets, a simple and novel method has been developed based on aptamer oligomerization. To this purpose, previously anti‐human TNF‐α aptamer named T1–T4 was trimerized through a trimethyl… read more here.
Keywords: tnf; aptamer; cutaneous shwartzman; anti tnf ... See more keywords
MicroRNA‐1225 activates Keap1‐Nrf2‐HO‐1 signalling to inhibit TNFα‐induced osteoclastogenesis by mediating ROS generation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3394
Abstract: The influence of miRNA‐1225‐5p (miR‐1225) and Keap1‐Nrf2 signalling on in vitro osteoclast differentiation in mouse models was studied along with the underlying mechanism. In differentiated bone marrow–derived macrophages (BMMs), downregulated miR‐1225 and upregulated Keap1 were… read more here.
Keywords: mir 1225; tnf; keap1 nrf2; ros generation ... See more keywords
TNF-α regulates the early development of avascular necrosis of femoral head by mediating osteoblast autophagy and apoptosis via p38 MAPK/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biology international"
DOI: 10.1002/cbin.11394
Abstract: Previous studies have shown that the tumor necrosis factor-α (TNF-α) levels in serum and bone tissues form avascular necrosis of femoral head (ANFH) patients were higher than that of normal individuals, indicating TNF-α might play… read more here.
Keywords: p38 mapk; autophagy apoptosis; tnf; apoptosis ... See more keywords
Nobiletin and xanthohumol counteract the TNFα‐mediated activation of endothelial cells through the inhibition of the NF‐κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11963
Abstract: Angiogenesis, a process characterized by the formation of new blood vessels from pre‐existing ones, is a crucial step in tumor growth and dissemination. Given the ability of tumors to interfere with multiple or different molecular… read more here.
Keywords: xanthohumol nobiletin; endothelial cells; tnf; angiogenesis ... See more keywords
Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25424
Abstract: The cytokine tumor necrosis factor (TNF) is involved in the regulation of physiological and pathophysiological processes in the central nervous system. In previous work, we showed that mice lacking constitutive levels of TNF exhibit a… read more here.
Keywords: tnf receptor; tnf; granule; granule cells ... See more keywords
Regulatory Safety Learning Driven by the Mechanism of Action: The Case of TNF‐α Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2127
Abstract: The summary of product characteristics (SmPCs) is an important information source that includes the adverse drug reactions (ADRs) associated with the drug. Drugs with the same mechanism of action are expected to have a similar… read more here.
Keywords: mechanism action; safety; tnf; tnf inhibitors ... See more keywords
TNF, TNF inducers, and TNFR2 agonists: A new path to type 1 diabetes treatment
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.2941
Abstract: In the past decade, interest in the century‐old tuberculosis vaccine, bacillus Calmette‐Guerin (BCG), has been revived for potential new therapeutic uses in type 1 diabetes and other forms of autoimmunity. Diverse clinical trials are now… read more here.
Keywords: diabetes treatment; type diabetes; tnf; bcg ... See more keywords
Microglia modulate TNFα-mediated synaptic plasticity.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24383
Abstract: The pro-inflammatory cytokine tumor necrosis factor α (TNFα) tunes the capacity of neurons to express synaptic plasticity. It remains, however, unclear how TNFα mediates synaptic positive (=change) and negative (=stability) feedback mechanisms. We assessed effects… read more here.
Keywords: tnf; mediated synaptic; plasticity; tnf mediated ... See more keywords
Necroptotic TNFα‐Syndecan 4‐TNFα Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4542
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease for which the underlying mechanism still remains unclear. Compared with apoptosis and autophagy, necroptosis causes greater harm to tissue homeostasis by releasing damage‐associated molecular patterns (DAMPs).… read more here.
Keywords: necroptosis; vicious cycle; therapeutic target; tnf ... See more keywords
Infliximab substantially re‐silenced Wnt/β‐catenin signaling and ameliorated doxorubicin‐induced cardiomyopathy in rats
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23312
Abstract: The release of inflammatory cytokines, namely tumor necrosis factor‐α (TNF‐α), plays an important role in the pathogenesis of cardiomyopathy. TNF‐α increases in plasma and in myocardium of heart failure patients. We aimed to investigate the… read more here.
Keywords: rpl ifx; tnf; wnt catenin; induced cardiomyopathy ... See more keywords